Survival trends in glioma: Experience at a tertiary care centre

Bose, Ratnadip; Narang, Kushal; Bhangale, Deepak; Kedia, Rishabh; Sharma, Vikas; Jha, Ajaya Nand

doi:10.4103/0028-3886.217968

Cited by 2 publications

(1 citation statement)

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“…Rett syndrome is characterized by cognitive impairment, problems with communication, stereotypic hand movements, and pervasive growth failure that follow a normal period of development during the first 6 to 18 months of life [17]. Rett syndrome involves the following stages with the prevailing symptoms in its progression:…”

Section: Signs and Symptomsmentioning

confidence: 99%

Rett Syndrome: A Review

Padala

2021

J Cli Pharm Res

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Rett syndrome (RS) is a progressive neuro developmental disorder with a significant severity of intellectual disability that occurs mainly in females. The syndrome was named after an Austrian physician called Andreas Rett who first described it in the medical literature in the year 1960. This disorder involves a regression of previously acquired skills followed by a period of typical development. Rett syndrome unveils multitude of symptoms such as deceleration in head growth, gait abnormalities, loss of purposeful hand movements often replaced with repetitive stereotypical movement, loss of speech and breathing abnormalities. It is caused by the mutations (de novo mutations) in methyl-CpG-binding protein 2 (MECP2) and Cyclin-dependent kinase-like 5(CDKL5) genes. In this article, various aspects of Rett Syndrome along with the gene modifying therapy were discussed. The road to cure Rett syndrome is paved with novel findings but also escalating many challenges. In the current scenario a special focus is laid in addressing the specific symptoms of Rett syndrome neglecting the underlying cause, which might impact the disease progression. Therefore a multidisciplinary team approach to treat the prevailing symptoms will maximise the patient’s abilities and provides an effective cure. This will involve major efforts on the part of translational researchers and collaboration with both pharmaceutical enterprises and regulatory agencies overseeing the critical safety concerns.

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Section: Signs and Symptomsmentioning

confidence: 99%