Survival Following Severe Aluminium Phosphide Poisoning

Pajoumand, Abdolkarim; Jalali, Naser; Abdollah, Mohammad; Shadnia, Shahin

doi:10.1002/jppr2002324297

Cited by 33 publications

(24 citation statements)

References 12 publications

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“…Fosforowodór jest toksyną oddziałującą na mitochondria, która zaburza proces wytwarzania białek i enzymów [2,3]. Częstość zgonów na skutek zatrucia fosforkiem glinu jest bardzo wysoka (60-80%), a zatrucia tym związ-kiem są uznawane za stan nagły w izbach przyjęć i na szpitalnych oddziałach ratunkowych [4]. Umyślne zatrucia fosforkiem glinu stanowią poważny problem w krajach rozwijających się [5].…”

Section: Wprowadzenieunclassified

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Jamshidi¹,

Ghorbani²,

Darvishi³

et al. 2016

amsik

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StreszczenieWstęp: Fosforek glinu, określany w Iranie jako "tabletka ryżowa" ze względu na stosowanie w ochronie upraw ryżu, jest jednym z najczęściej stosowanych pestycydów na świecie. W kontakcie z wodą, parą lub kwasem żołądkowym uwalnia gaz -fosforowodór, co może wywoływać zatrucie. Zatrucie fosforowodorem jest często stosowaną metodą samobójstwa, a liczba takich przypadków stale rośnie. W dwóch trzecich przypadków zatrucie fosforowodorem ma skutek śmiertelny. Celem badania była ocena danych dotyczących epidemiologii klinicznej oraz zmian parametrów laboratoryjnych u pacjentów po zatruciu "tabletką ryżową". Materiały i metody: W badaniu uwzględniono łącznie 23 pacjentów z zatruciem fosforkiem glinu hospitalizowanych w szpitalu Razi w mieście Ahwaz w latach 2010-2015. Dane analizowano przy użyciu metod statystyki opisowej oraz testów statystycznych. Wyniki: Średni wiek pacjentów wynosił 27,2 ±7,3 roku. Mężczyźni stanowili 60,9% analizowanej grupy pacjentów. U 8,7% pacjentów stwierdzono hiponatremię, a u 21,7% -hipokaliemię. W większości przypadków poziom sodu i potasu mieścił się w granicach normy. U 91% pacjentów występowała kwasica. W większości przypadków stwierdzano także obniżenie poziomu wodorowęglanów w surowicy. Średni okres od zatrucia do hospitalizacji wynosił 1,48 ±0,76 godzin. Wnioski: Przebieg zmian w poziomie elektrolitów i innych parametrów laboratoryjnych może być dobrym markerem ciężkości zatrucia oraz stanu klinicznego pacjenta. Niezbędne są dodatkowe badania w celu potwierdzenia powyższej zależności.Słowa kluczowe: fosforek glinu, tabletki ryżowe, pestycydy, zatrucie. AbstractIntroduction: Aluminium phosphide or rice tablet is one of the most common pesticides around the world. The substance releases phosphine gas in the presence of water, steam or stomach acid which can lead to poisoning. Phosphine poisoning is more about suicide the number of which is increasing day by day. Two-thirds of patients lose their lives. The aim of this study was to evaluate the data on the clinical epidemiology and laboratory changes in patients poisoned with rice tablets.

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Section: Wprowadzenieunclassified

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Jamshidi¹,

Ghorbani²,

Darvishi³

et al. 2016

amsik

View full text Add to dashboard Cite

show abstract

“…Similarly, reports to the National Poisons Centre in Delhi indicate that aluminium phosphide is the pesticide most commonly ingested by children (Gupta, et al, 2003). Much smaller numbers or only sporadic cases of phosphide poisoning have been reported from the remainder of the world, including Australia (Nocera, et al, 2000), Denmark (Andersen, et al, 1996), France (Anger, et al, 2000), Germany ), Greece (Frangides & Pneumatikos, 2002), Iran (Pajoumand, et al, 2002), Jordan (Abder-Rahman, et al, 2000, Morocco (Idali, et al, 2005;Hajouji, et al, 2006;, Nepal (Lohani, et al, 2000), Sri Lanka (Roberts, et al, 2006), Turkey , the United Kingdom Lawler & Thomas, 2007), Canada, the United States (Broderick & Birnbaum, 2002, the former USSR (Rimalis & Bochkarnikov, 1978), and Yugoslavia (Curcic & Dadasovic, 2001). A single death from ingestion of a falsely labeled rodenticide bait has been reported (Azoury & Levin, 1998).…”

Section: Ingestion Of Phosphidesmentioning

confidence: 97%

“…A single death from ingestion of a falsely labeled rodenticide bait has been reported (Azoury & Levin, 1998). Phosphide rodenticides were responsible for nine out of 349 deaths in 35,580 poisoning admissions to Loghman Hakim hospital poison center in Tehran (Pajoumand, et al, 2002).…”

Section: Ingestion Of Phosphidesmentioning

confidence: 99%

Aluminium Phosphide Poisoning

Mostafazadeh¹

2012

Toxicity and Drug Testing

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“…Carbamates quickly paralyze the nervous system of insects by blocking the production and action of cholinesterase thereby known for its rapid knockdown effect [1]. Numerous incidents of acute carbamate poisoning have resulted from inhalation of sprays or contamination of crops or food.…”

Section: Introductionmentioning

confidence: 99%

Methomyl induced gonadal dysfunction, biochemical contents and enzyme activities in male albino mice

Bb¹,

Si²

2010

Int J of Biot Appl

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Abstract-Methomyl (S-methyl-1-N [(methyl carbamoyl) oxy] thio acetimidate, is a carbamate broad spectrum insecticide. The Swiss albino mice were administered orally 1, 2, 3, and 4 mg/kg body wt methomyl for 30 days and effective dose 4 mg/kg for 5, 10, and 20 days to know the dose and durational effect on testes and biochemical contents. The mice were sacrificed on day 31 st or 24 hours after the terminal exposure. Testes, epididymis, vasa deferentia, seminal vesicles, prostate, coagulatory and Cowper's glands weight decreased significantly with 2, 3 and 4 mg/kg/day and in 4mg/kg /day for 10 and 20 days of methomyl treatment.Histologic studies of the testes revealed anti-spermatogenic and anti-steroidogenic effects of methomyl reflected by significant decrease in the number and diameter of spermatogonia, primary spematocytes, secondary spermatocytes, spermatids and Leydig cells in the mice treated with 2, 3 and 4 mg/kg/day and in 4 mg/kg /day for 10 and 20 days of methomyl treatment, except with 2 mg/kg/day methomyl treatment number of primary spematocytes, Leydig cells, diameter of spermatogonia, and in 4 mg/kg/day methomyl for 10 days treatment the number of spermatogonia, leydig cells and diameter of primary spermatocytes not changed significantly when compared with controls. Biochemical studies of testis and epididymis showed methomyl at doses of 2, 3 and 4 mg/kg/day and in 4 mg/kg /day for 10 and 20 days of methomyl treatment caused significant decrease in the levels of DNA, RNA, protein, glycogen and sialic acid whereas cholesterol increased significantly. However, treatment with 1, 2 mg / kg/ day and 4 mg / kg /day for 5 days methomyl caused no significant change in epididymal biochemical contents when compared with control. Study on enzyme activities in testis and epididymis revealed that the treatment with 3 and 4 mg/kg/day and 4 mg/kg /day for 20 days of methomyl caused significant decrease in the activities of succinic dehydrogenase (SDH), ions ATPase (Na + -K + ATPase, Ca ++ ATPase, Mg ++ ATPase) and acid phosphatase (ACP) were decreased significantly, except with 3 mg/kg/day methomyl treatment where Ca ++ ATPase activity in testes and epididymis not changed significantly. However, lactate dehydrogenase (LDH) and alkaline phosphatase (AKP) activities were increased significantly. The testis 3β hydroxysteroid dehydrogenase (3βHSD) decreased significantly with 3 and 4 mg/kg /day and in 4 mg/kg /day for 10 and 20 days of methomyl treatment when compared with controls. However, there was no significant change in testes and accessory reproductive organs, number and diameter of spermatogonia and Leydig cells and biochemical contents of testis and epididymis with 1 mg/kg/day and in 4 mg/kg /day for 5 days of methomyl treatment. These observed effects of methomyl on testes and accessory reproductive organs weight, testis histology, biochemical contents and enzyme activities in testis and epididymis may be due to toxic effect or hormonal imbalance in any of the stage in the hypothalamo-hypophysial-testicular ...

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Survival Following Severe Aluminium Phosphide Poisoning

Cited by 33 publications

References 12 publications

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Aluminium Phosphide Poisoning

Methomyl induced gonadal dysfunction, biochemical contents and enzyme activities in male albino mice

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