Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost ± hyperthermia for glioblastoma multiforme

Sneed, Penny K.; Stauffer, Paul R.; Diederich, Chris J.; McDermott, Michael W.; Lamborn, Kathleen R.; Weaver, Keith A.; Prados, Michael D.; Chang, Susan M.; Malec, Mary; Spry, Laura; Lamb, Sharon; Voss, Brigid; Wara, William M.; Larson, David A.; Phillips, Theodore L.; Gutin, Philip H.

doi:10.1016/s0360-3016(97)85343-6

Cited by 275 publications

(104 citation statements)

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“…A multivariate analysis adjusting for age and KPS showed that improved survival was significantly associated with randomization to "heat" with a hazard ration of 0.51. (77) …”

Section: Randomized Trials Of Hyperthermia and Radiation Cns Malignanmentioning

confidence: 99%

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hurwitz

Stauffer

2014

Seminars in Oncology

118

104

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“…A multivariate analysis adjusting for age and KPS showed that improved survival was significantly associated with randomization to "heat" with a hazard ration of 0.51. (77) …”

Section: Randomized Trials Of Hyperthermia and Radiation Cns Malignanmentioning

confidence: 99%

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hurwitz

Stauffer

2014

Seminars in Oncology

118

104

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“…Various clinical trials have demonstrated the efficacy of such combinations [2][3][4][5][6]. However, despite the promising results, hyperthermia has not yet been established in clinical routine.…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

734

556

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Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.

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“…[1][2][3][4][5] This has been demonstrated in multiple Phase III randomized studies, including a breast cancer trial, whereby 60% local control rate (LCR) was achieved when recurrent chestwall breast cancer was treated with RT plus HT vs. 39% LCR with RT alone. 5 These highly promising data have continued to motivate us to develop improved biological therapies, which can further improve these clinical data.…”

mentioning

confidence: 99%

Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer

Szmitko

Brade

et al. 2003

Cancer Gene Ther

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We have previously demonstrated that protein kinase B (PKB) is a mediator of heat-induced apoptosis for human breast cancer cells. To investigate the therapeutic potential of abrogating the function of this important survival protein, a novel replication-deficient adenovirus was constructed, wherein a mutant, kinase-inactive PKB gene (AAA) was inserted downstream of the CMV promoter. Two human breast cancer cell lines, MCF-7 and MDA-468, were treated, along with the MCF-10 serving as a ''normal'' mammary epithelial comparator. Apoptosis was increased with adv.AAA (25 PFU/cell) infection alone, but was significantly enhanced with the addition of heat exposure. Differential survival was observed with the MDA-468 cancer cells being more sensitive than the MCF-7 cells. The MCF-10 cells, in contrast, were most resistant to these treatments. Results from the clonogenic assay reflected the apoptosis data, with an apparent additive interaction between adv.AAA and hyperthermia treatments, again with greater differential sensitivity of the malignant, compared to the ''normal'' mammary epithelial cells. Heat or adv.b-gal treatments led to phosphorylation of PKB and Forkhead, but this phosphorylation was reduced with adv.AAA therapy. In parallel, the combination of adv.AAA and heat treatment reduced PKB kinase activity more so than with either heat or adv.b-gal alone. In conclusion, our results demonstrate that inhibition of the PKB-dependent survival pathway will promote apoptosis and thermosensitization in malignant breast cancer cells, with relative sparing of their normal counterpart, suggesting that a therapeutic gain could be achievable using this therapeutic strategy.

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Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost ± hyperthermia for glioblastoma multiforme

Cited by 275 publications

References 0 publications

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

Clinical applications of magnetic nanoparticles for hyperthermia

Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer

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