Survival analysis in a sample of oral cancer patients at a reference hospital in Rio de Janeiro, Brazil

Leite, Iuri Costa; Koifman, Sérgio

doi:10.1016/s1368-8375(98)00019-0

Cited by 54 publications

(62 citation statements)

References 17 publications

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“…Apparently, there are no prognostic differences between males and females, [7][8][9] although some authors have reported lower survival rates in females, attributed to delay in seeking medical care and lower acceptance of treatment. 10 The correlation of prognosis with age seems controversial, and some authors show no relationship between them, 7-9,11 whereas others demonstrate worse prognosis in older patients. 10,12 Tobacco and alcohol.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…10 The correlation of prognosis with age seems controversial, and some authors show no relationship between them, 7-9,11 whereas others demonstrate worse prognosis in older patients. 10,12 Tobacco and alcohol. Although some results deny any association between survival and smoked tobacco or alcohol consumption, 7 most authors report higher mortality in smokers and alcohol drinkers.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…Although some results deny any association between survival and smoked tobacco or alcohol consumption, 7 most authors report higher mortality in smokers and alcohol drinkers. 10,12,13 Betel quid chewing (a common habit in some regions of Asia and some Asian communities in the western world) has been specifically correlated with poorer prognosis. 7 Smokers and alcohol drinkers seem to be at higher risk for the development of second primary oral cancer than nonsmokers and nondrinkers, thus facing more onerous outcomes.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…Apparently, the outcome is somewhat worse for patients with lower socioeconomic status and education, most likely because of poorer oral hygiene and more difficult access to medical care. 10 Diagnostic delays. It seems highly likely that diagnostic delays raise the probability of higher tumor growth and spread, consequently aggravating the prognosis.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

“…Most authors have established significant correlations between lower histologic differentiation and poorer prognosis, 7,9,20,27,37 but others did not find such association. 8,10,11 Perineural invasion. Perineural invasion apparently correlates with higher probability of regional and distant metastases, higher depth of tumor invasion, lower differentiation, and lower 5-year survival rates in OSCC.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

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Oral squamous cell carcinoma: Review of prognostic and predictive factors

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

See 3 more Smart Citations

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

517

420

View full text Add to dashboard Cite

Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome—A Taiwan Cancer Registry national database analysis

et al. 2018

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Conduct an accurate risk assessment of resected oral cavity squamous cell carcinoma (OSCC) patients by accessing a nationwide systemic investigation is pivotal to improve treatment outcomes. In this article, we tried to determine the impact of different prognostic factors for OSCC patients who received adjuvant radiotherapy (RT) after curative surgery, using Taiwan's national cancer registry database (TCR). A nationwide, large population‐based study was conducted using TCR with patients identified from 2007 to 2015. The study variables included age, gender, cancer subsites, stage, histology grade, margin and extra‐nodal extension (ENE) status, treatment type, surgery to RT interval (ORI), total RT treatment time (RTT), and RT dose. Univariate and multivariate analysis were performed to identify predictors of the variables associated with overall survival (OS), cause‐specific survival (CSS), local‐regional relapse‐free survival (LRFS), and distant metastasis‐free survival (DMFS). 8986 OSCC patients treated with surgery and adjuvant RT were analyzed. In multivariate analysis, worse outcomes were associated with males, older age, subsite in the oral tongue, advanced stage, higher histologic grade, involved margin, and positive ENE. ORI only showed an adverse trend in LRFS, when exceeding 7 weeks (P = .06). RTT >8 weeks was a significant poor predictor in OS, CSS and LRFS (P < .001). Extreme RT dose (>70 Gy or ≤50 Gy) also demonstrated an adverse impact on the outcomes. Prolonged RT treatment time and extreme RT doses were identified as significantly poor prognostic predictors in OSCC patients who received adjuvant RT after curative surgery.

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