Survival After Acute Mercury Vapor Poisoning

Jaffe, Kenneth M.; Shurtleff, David B.; Robertson, William O.

doi:10.1001/archpedi.1983.02140340033008

Cited by 48 publications

(15 citation statements)

References 8 publications

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“…Most cases of pneumothorax and pneumomediastinum in the course of mercury vapour poisoning have been reported in children 12,14,15 and very few in adults. 16 …”

Section: Discussionmentioning

confidence: 99%

Occupational mercury vapour poisoning with a respiratory failure, pneumomediastinum and severe quadriparesis

Śmiechowicz

Skoczyńska

Nieckula-Szwarc

et al. 2017

SAGE Open Medical Case Reports

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Objectives:Despite restrictions, mercury continues to pose a health concern. Mercury has the ability to deposit in most parts of the body and can cause a wide range of unspecific symptoms leading to diagnostic mistakes.Methods and results:We report the case of severe mercury vapour poisoning after occupational exposure in a chloralkali plant worker that resulted in life-threatening respiratory failure, pneumomediastinum and quadriparesis.Conclusions:Prolonged mechanical ventilation and treatment with penicillamine and spironolactone was used with successful outcome.

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“…Most cases of pneumothorax and pneumomediastinum in the course of mercury vapour poisoning have been reported in children 12,14,15 and very few in adults. 16 …”

Section: Discussionmentioning

confidence: 99%

Occupational mercury vapour poisoning with a respiratory failure, pneumomediastinum and severe quadriparesis

Śmiechowicz

Skoczyńska

Nieckula-Szwarc

et al. 2017

SAGE Open Medical Case Reports

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“…However, the extent of the adverse effects induced by Hg in an organism depends on the form of Hg at the time of exposure, the duration of exposure, and the route of exposure. Exposure to all forms of Hg, at least to some extent, has been shown to cause deleterious effects in the cardiovascular system (Carmignani et al, 1992;Soni et al, 1992;Warkany and Hubbard, 1953;Wakita, 1987), gastrointestinal system (Afonso and deAlvarez, 1960;Bluhm et al, 1992;Lundgren and Swensson, 1949;Murphy et al, 1979), liver (Jaffe et al, 1983;Murphy et al, 1979;Samuels et al, 1982), kidneys (Murphy et al, 1979;Rowens et al, 1991;Samuels et al, 1982;Yasutake et al, 1991), and neurological system (Jaffe et al, 1983;Kutsuna, 1968;Lin and Lim, 1993;Tsubaki and Takahashi, 1986).…”

Section: Mercurymentioning

confidence: 99%

Molecular and ionic mimicry and the transport of toxic metals

Bridges

Zalups

2005

Toxicology and Applied Pharmacology

667

460

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Despite many scientific advances, human exposure to, and intoxication by, toxic metal species continues to occur. Surprisingly, little is understood about the mechanisms by which certain metals and metal-containing species gain entry into target cells. Since there do not appear to be transporters designed specifically for the entry of most toxic metal species into mammalian cells, it has been postulated that some of these metals gain entry into target cells, through the mechanisms of ionic and/or molecular mimicry, at the site of transporters of essential elements and/or molecules. The primary purpose of this review is to discuss the transport of selective toxic metals in target organs and provide evidence supporting a role of ionic and/or molecular mimicry. In the context of this review, molecular mimicry refers to the ability of a metal ion to bond to an endogenous organic molecule to form an organic metal species that acts as a functional or structural mimic of essential molecules at the sites of transporters of those molecules. Ionic mimicry refers to the ability of a cationic form of a toxic metal to mimic an essential element or cationic species of an element at the site of a transporter of that element. Molecular and ionic mimics can also be sub-classified as structural or functional mimics. This review will present the established and putative roles of molecular and ionic mimicry in the transport of mercury, cadmium, lead, arsenic, selenium, and selected oxyanions in target organs and tissues.

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“…These include, but are not limited to, the cardiovascular (Carmignani et al 1992; Soni et al 1992; Wakita 1987; Wang et al 2000; Warkany and Hubbard 1953), gastrointestinal (Afonso and De Alvarez 1960; Bluhm et al 1992; Lundgren and Swensson 1949; Murphy et al 1979), neurological (Jaffe et al 1983; Lin and Lim 1993), hepatobiliary (Jaffe et al 1983; Murphy et al 1979; Samuels et al 1982), and renal (Murphy et al 1979; Rowens et al 1991; Samuels et al 1982) systems.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms involved in the transport of mercuric ions in target tissues

2016

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Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are taken up by and accumulate in numerous organs, including brain, intestine, kidney, liver, and placenta. In order to understand the toxicological effects of exposure to mercury, a thorough understanding of the mechanisms that facilitate entry of mercuric ions into target cells must first be obtained. A number of mechanisms for the transport of mercuric ions into target cells and organs have been proposed in recent years. However, the ability of these mechanisms to transport mercuric ions and the regulatory features of these carriers have not been characterized completely. The purpose of this review is to summarize the current findings related to the mechanisms that may be involved in the transport of inorganic and organic forms of mercury in target tissues and organs. This review will describe mechanisms known to be involved in the transport of mercury and will also propose additional mechanisms that may potentially be involved in the transport of mercuric ions into target cells.

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Survival After Acute Mercury Vapor Poisoning

Cited by 48 publications

References 8 publications

Occupational mercury vapour poisoning with a respiratory failure, pneumomediastinum and severe quadriparesis

Occupational mercury vapour poisoning with a respiratory failure, pneumomediastinum and severe quadriparesis

Molecular and ionic mimicry and the transport of toxic metals

Mechanisms involved in the transport of mercuric ions in target tissues

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