Survey of MicroRNA expression in pediatric brain tumors

Birks, Diane K.; Barton, Valerie N.; Donson, Andrew M.; Handler, Michael H.; Vibhakar, Rajeev; Foreman, Nicholas K.

doi:10.1002/pbc.22723

Cited by 93 publications

(89 citation statements)

References 41 publications

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“…Deregulation of some of these miRNAs has been associated with carcinogenesis: i) miR-142-3p with acute myeloid leukemia [45], T-cell leukemogenesis [46], esophageal squamous cell carcionoma [47], and hepatocellular carcinoma [48]; ii) miR-142-5p with T cell chronic lymphocytic leukemia [49] and in pediatric brain tumors [50], and iii) miR-199a-5p with hepatocellular carcinoma [51,52], ovarian cancer [53], and oral squamous cell carcinoma [54]. In addition, miR-342-3p has been associated with cellular proliferation [55], and has been suggested as a potential biomarker for multiple myeloma [56] and prion disease [57].…”

Section: Discussionmentioning

confidence: 99%

Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients

et al. 2013

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BackgroundRegardless the regulatory function of microRNAs (miRNA), their differential expression pattern has been used to define miRNA signatures and to disclose disease biomarkers. To address the question of whether patients presenting the different types of diabetes mellitus could be distinguished on the basis of their miRNA and mRNA expression profiling, we obtained peripheral blood mononuclear cell (PBMC) RNAs from 7 type 1 (T1D), 7 type 2 (T2D), and 6 gestational diabetes (GDM) patients, which were hybridized to Agilent miRNA and mRNA microarrays. Data quantification and quality control were obtained using the Feature Extraction software, and data distribution was normalized using quantile function implemented in the Aroma light package. Differentially expressed miRNAs/mRNAs were identified using Rank products, comparing T1DxGDM, T2DxGDM and T1DxT2D. Hierarchical clustering was performed using the average linkage criterion with Pearson uncentered distance as metrics.ResultsThe use of the same microarrays platform permitted the identification of sets of shared or specific miRNAs/mRNA interaction for each type of diabetes. Nine miRNAs (hsa-miR-126, hsa-miR-1307, hsa-miR-142-3p, hsa-miR-142-5p, hsa-miR-144, hsa-miR-199a-5p, hsa-miR-27a, hsa-miR-29b, and hsa-miR-342-3p) were shared among T1D, T2D and GDM, and additional specific miRNAs were identified for T1D (20 miRNAs), T2D (14) and GDM (19) patients. ROC curves allowed the identification of specific and relevant (greater AUC values) miRNAs for each type of diabetes, including: i) hsa-miR-1274a, hsa-miR-1274b and hsa-let-7f for T1D; ii) hsa-miR-222, hsa-miR-30e and hsa-miR-140-3p for T2D, and iii) hsa-miR-181a and hsa-miR-1268 for GDM. Many of these miRNAs targeted mRNAs associated with diabetes pathogenesis.ConclusionsThese results indicate that PBMC can be used as reporter cells to characterize the miRNA expression profiling disclosed by the different diabetes mellitus manifestations. Shared miRNAs may characterize diabetes as a metabolic and inflammatory disorder, whereas specific miRNAs may represent biological markers for each type of diabetes, deserving further attention.

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Section: Discussionmentioning

confidence: 99%

Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients

et al. 2013

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“…[110] MicroRNAs have also been shown to play an important role in various CNS malignancies, and miR-142-5p and miR-25 are upregulated in all of them. [111] In MB, miR-21 suppression inhibited tumor migration. [112] MiR-183 has a pro-tumorigenic effect in the MYC-driven MB subgroup through the inhibition of apoptosis, deregulation of the mTOR pathway and modulation of cell motility and migration.…”

Section: Emt Cell Invasion and Motilitymentioning

confidence: 97%

The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

Crespo¹,

Kind²,

Arcaro³

2016

JCMT

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The PI3K/AKT/mTOR (PAM) pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer progression. It has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children, malignant gliomas and medulloblastomas (MB). In these tumors, the PAM network controls key functions necessary for cell invasion and metastasis, such as cell motility. This review summarizes the current knowledge about the role of PAM signaling in cell invasion and metastasis in gliomas and MB. Current approaches to inhibit cell invasion and metastasis by targeting the PAM pathway will also be discussed.

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“…Ultimately, we aimed to identify and provide additional data regarding potential miRNA expression signatures relative to prognosis of pediatric MBs and AT/RTs, specifically. At present, there have been comparatively limited reports focusing on identifying miRNA biomarkers related to MB and AT/RT diagnostics and therapeutics [23,26,28,32]. To our knowledge, this is the first attempt aiding specifically to evaluate an association between miRNA expression patterns and disease progression or patient outcome in pediatric MBs and AT/RTs and this is the first attempt that used meta-analysis to validate findings.…”

Section: Discussionmentioning

confidence: 97%

“…However, as the number of novel miRNAs is still increasing, large-scale screening is necessary to profile the global miRNA expression. To our knowledge, only a few studies applying miRNA microarrays have been conducted [24,28,29] in pediatric brain tumors. MiRNA microarrays afford the most commonly used tool for the large-scale screening of miRNA expression.…”

Section: Introductionmentioning

confidence: 99%

Microrna expression signatures predict patient progression and disease outcome in pediatric embryonal central nervous system neoplasms

et al. 2014

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Background: Although, substantial experimental evidence related to diagnosis and treatment of pediatric central nervous system (CNS) neoplasms have been demonstrated, the understanding of the etiology and pathogenesis of the disease remains scarce. Recent microRNA (miRNA)-based research reveals the involvement of miRNAs in various aspects of CNS development and proposes that they might compose key molecules underlying oncogenesis. The current study evaluated miRNA differential expression detected between pediatric embryonal brain tumors and normal controls to characterize candidate biomarkers related to diagnosis, prognosis and therapy.

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Survey of MicroRNA expression in pediatric brain tumors

Cited by 93 publications

References 41 publications

Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients

Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients

The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

Microrna expression signatures predict patient progression and disease outcome in pediatric embryonal central nervous system neoplasms

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