Survey of fungi and yeast in polymicrobial infections in chronic wounds

Dowd, Scot E.; Hanson, John D.; Rees, Eric; Wolcott, Randall D.; Zischau, A M; Sun, Yan; White, Jennifer S.; Smith, D M; Kennedy, John Pendleton; Jones, Curtis E.

doi:10.12968/jowc.2011.20.1.40

Cited by 155 publications

(106 citation statements)

References 72 publications

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“…Chronic infections such as chronic wounds comprise 60-80% of infectious diseases in humans [20]. Colonisation of fungi in wounds is associated with the use of broadspectrum antibiotics [21].…”

Section: Fusarium Biofilmsmentioning

confidence: 99%

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Dryden

Cooke

Salib

et al. 2017

Journal of Global Antimicrobial Resistance

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Reactive oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection, http://dx.doi.org/10. 1016/j.jgar.2016.12.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Fusarium Biofilmsmentioning

confidence: 99%

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Dryden

Cooke

Salib

et al. 2017

Journal of Global Antimicrobial Resistance

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“…These results are in agreement with the findings of Dowd SE et al 13 Samples from unopened abscess cavities and surgical sites showed no growth of fungi. 14 From skin and its appendages dermatophytes were the major isolates consisting of Trichophyton rubrum, T. mentagrophyte, Microsporum and Epidermophyton spp. followed by the Candida.…”

Section: Resultsmentioning

confidence: 99%

Spectrum of Fungal Isolates in Different Clinical Samples

D¹,

Sahu²,

Hembram³

2017

jemds

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BACKGROUNDFungal infections are on the rise due to changing practices in medical care; increase in the immunocompromised states, and due to increase in the use of antibiotics and steroid therapy. Currently, the awareness levels among the medical personnel regarding fungal diseases are lacking. More and more cases of fungal infections are being reported from cases of AIDS, malignancy, and transplant recipients, patients in ICU or on steroid therapy. Indiscriminate use of antibiotic therapy is another reason for the growing incidence of fungal infections. MATERIALS AND METHODSA retrospective study was undertaken to know the burden of fungal infection in different clinical samples. A total number of 3146 clinical samples from different in-patient departments processed in the microbiology laboratory of a tertiary care teaching hospital were analysed. The samples were processed for microscopy by KOH mount, Gram stain, negative stain, Lactophenol cotton blue stain and culture on SDA with Chloramphenicol, BHI broth (for blood), Dalmau culture on CMA, Slide culture and relevant biochemical tests depending on the type of sample and were identified by standard algorithm. RESULTSIt was seen that most of the isolates belonged to yeasts comprising C. albicans (45%) followed by C. tropicalis (33.6%). The samples from the genital tract, oropharyngeal swabs, blood, urine, CSF and faeces showed no isolation of filamentous fungi. Moulds were mainly isolated from respiratory samples, skin and its appendages, aural swabs and deep wounds. Dermatophytes formed the major isolates from skin and its appendages. CONCLUSIONA more detailed study is needed to know the socio-epidemiological prevalence of these infections and their burden in the community and in hospitalised patients.

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“…Approximately 7-23% of chronic wounds contain fungi. 32,33 The figure rises slightly to 27% in infected diabetic wounds requiring hospitalisation for treatment. 34 A study from 2012 has demonstrated that such patients show marked improvement in wound healing rates when treated with an antifungal compared with a best standard care control.…”

Section: Resultsmentioning

confidence: 99%

Topical steroids for chronic wounds displaying abnormal inflammation

Nikkhah

Dheansa

Bosanquet

et al. 2013

annals

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INTRODUCTION Chronic, non-healing wounds are often characterised by an excessive, and detrimental, inflammatory response. We review our experience of using a combined topical steroid, antibiotic and antifungal preparation in the treatment of chronic wounds displaying abnormal and excessive inflammation. METHODS A retrospective review was undertaken of all patients being treated with a topical preparation containing a steroid (clobetasone butyrate 0.05%), antibiotic and antifungal at a tertiary wound healing centre over a ten-year period. Patients were selected as the primary treating physician felt the wounds were displaying excessive inflammation. Healing rates were calculated for before and during this treatment period for each patient. Changes in symptom burden (pain, odour and exudate levels) following topical application were also calculated. RESULTS Overall, 34 ulcers were identified from 25 individual patients (mean age: 65 years, range: 37-97 years) and 331 clinic visits were analysed, spanning a total time of 14,670 days (7,721 days 'before treatment' time, 6,949 days 'during treatment' time). Following treatment, 24 ulcers demonstrated faster rates of healing, 3 ulcers showed no significant change in healing rates and 7 were healing more slowly (p=0.0006). Treatment generally reduced the burden of pain and exudate, without affecting odour. CONCLUSIONS In normal wound healing, inflammation represents a transient but essential phase of tissue repair. In selected cases, direct application of a steroid containing agent has been shown to improve healing rates, presumably by curtailing this phase. Further evaluation is required to establish the role of preparations containing topical steroids without antimicrobials in the management of chronic wounds.

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Survey of fungi and yeast in polymicrobial infections in chronic wounds

Cited by 155 publications

References 72 publications

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Spectrum of Fungal Isolates in Different Clinical Samples

Topical steroids for chronic wounds displaying abnormal inflammation

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