Surveillance recommendations based on an exploratory analysis of respiratory syncytial virus reports derived from the European Influenza Surveillance System

Meerhoff, T J; Fleming, Douglas; Smith, Ann; Mosnier, Anne; Gageldonk-Lafeber, Arianne B van; Paget, W J

doi:10.1186/1471-2334-6-128

Cited by 25 publications

(26 citation statements)

References 24 publications

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“…The season of human influenza reported previously during the rainy season in Senegal is confirmed [Dosseh and Rogier, 1996;Dosseh et al, 2000]; episodes of influenza viruses B in late June and episodes of influenza viruses A between mid-September and mid-October were identified. The distribution of hRSV in sub-tropical countries throughout the year is still unknown; in Europe and the USA, symptomatic hRSV infections occur mainly in young children during the cold season [Meerhoff et al, 2006;CDC, 2007]. However, two simultaneous clusters of acute respiratory infections were observed: one consisted of influenza virus A and occurred in Dielmo, whereas the other cluster concerned hRSV in Ndiop between mid-September and mid-October.…”

Section: Discussionmentioning

confidence: 99%

Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: The EVIRA project

Niang

Diop

Sarr

et al. 2010

Journal of Medical Virology

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Acute respiratory infection is one of the leading causes of child morbidity, especially in developing countries. Viruses are recognized as the predominant causative agents of acute respiratory infections. In Senegal, few data concerning the causes of respiratory infections are available, and those known relate mainly to classical influenza infections. Clinical and virological surveillance of acute respiratory infections was carried out in a rural community in children less than 5 years old. A standardized questionnaire was used and a nasopharyngeal swab sample was collected from each patient. These samples were tested for the detection of 20 respiratory viruses by multiplex RT-PCR or by viral culture. A total of 82 acute respiratory episodes were included, and 48 (58.5%) were found to be positive, with a total of 55 viral detections; several samples were positive for two (n = 5) or 3 (n = 1) viruses. Ten different viruses were identified: influenza viruses A, B, and C (n = 25), human respiratory syncytial virus type A (n = 13), rhinoviruses (n = 8), human coronaviruses type 229E and NL63 (n = 6), parainfluenza viruses 3 and 4 (n = 2), and bocavirus (n = 1). These results provide evidence on the importance and the diversity of viruses as causative agents of acute respiratory infections in children living in a rural community in Senegal. The establishment of sentinel surveillance sites could help estimate the burden of acute respiratory infection in the pediatric population and should help prepare the health care systems to identify and respond to new viral respiratory emergencies.

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Section: Discussionmentioning

confidence: 99%

Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: The EVIRA project

Niang

Diop

Sarr

et al. 2010

Journal of Medical Virology

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“…In children RSV causes bronchiolitis, a leading cause of morbidity and mortality worldwide 5. In Europe, RSV is associated with approximately 40% of hospital admissions for acute respiratory infection in children <2 years of age, with the youngest infants experiencing the most severe disease 6. Supportive therapy (oxygen and/or fluids) has been the mainstay of treatment for the majority of children with bronchiolitis for the last 50 years 7.…”

Section: Introductionmentioning

confidence: 99%

Primary airway epithelial cultures from children are highly permissive to respiratory syncytial virus infection

Fonceca

Flanagan

Trinick

et al. 2011

Thorax

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Background Respiratory syncytial virus (RSV) infection of airway epithelial cells (AECs) is an important initial event in RSV bronchiolitis. AEC immunological responses are thought to be critical in driving the subsequent inflammation in the airway. This study examined viral replication, cytotoxicity and cytokine production in cultures of primary AECs from children compared with responses to RSV infection in an immortalised epithelial cell line and to those from infants with RSV bronchiolitis. Methods RSV replication, proinflammatory cytokine responses and cytotoxicity in RSV-infected primary AEC cultures derived from bronchial brushings from the lungs of children were compared with those seen in BEAS-2B cultures, as well as AECs and bronchoalveolar lavage fluid collected from children with and without RSV bronchiolitis. Results Viral replication, cytotoxicity and inflammatory cytokine production were greater in primary AEC cultures than in BEAS-2B cells. Different response patterns were observed, with RSV infection of primary AEC cultures causing distinct peaks of viral replication and matched cytotoxic responses. Some primary AEC culture immunological responses, such as interleukin 8, were similar in magnitude to those seen in clinical samples from the lungs of children with RSV bronchiolitis. Although variable amounts of RSV were detected by PCR in freshly isolated primary AECs, RSV was not detected by immunocytochemistry. Conclusion This is one of the first studies to examine comprehensively the responses to RSV infection in primary AEC cultures from children and shows marked differences from those of a commercially available immortalised human cell line but reassuring similarities to results found in vivo. This suggests that future work investigating responses of AECs to RSV infection should use primary AEC cultures.

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“…Otros estudios que analizaron varias temporadas también encontraron cocirculación de ambos subgrupos, con alternancia de uno sobre otro según la temporada 3,21 . El patrón epidemiológico encontrado en la infección por el VRS es consistente dentro de la variabilidad de esta infección entre temporadas y lugares 19,22 . Coincidiendo con varios estudios, no encontramos diferencias estadísticamente significativas en las manifestaciones clíni-cas, radiológicas o analíticas, ni en la gravedad o en el pronóstico, entre los casos debidos al subgrupo VRS-A y VRS-B 3,23 .…”

Section: Discussionunclassified

Comparison of clinical features and diagnosis between the A and B subgroups of respiratory syncytial virus.

2017

An Sist Sanit Navar

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results. A total of 198 children under 5 were diagnosed with RSV by RT-PCR: 55 (28%) were RSV-A, 132 (67%) RSV-B and 11 (5%) were positive for both subgroups. No differences were observed between subgroups in medical history, symptoms, radiological and analytical findings, and severity. The sensitivity of RADT for RSV was 52%, higher for RSV-A (69%) than for RSV-B (44%, p=0.001).conclusions. The two RSV subgroups were indistinguishable in symptoms and prognosis. The sensitivity of RADT compared to RT-PCR was low and limits its usefulness for clinical decision-making.

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Surveillance recommendations based on an exploratory analysis of respiratory syncytial virus reports derived from the European Influenza Surveillance System

Cited by 25 publications

References 24 publications

Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: The EVIRA project

Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: The EVIRA project

Primary airway epithelial cultures from children are highly permissive to respiratory syncytial virus infection

Comparison of clinical features and diagnosis between the A and B subgroups of respiratory syncytial virus.

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