Surveillance of antimicrobial resistance among Escherichia coli in wastewater in Stockholm during 1 year: does it reflect the resistance trends in the society?

Kwak, Young-Keun; Colque, Patricia; Byfors, Sara; Giske, Christian G.; Möllby, R.; Kühn, Inger

doi:10.1016/j.ijantimicag.2014.09.016

Cited by 93 publications

(62 citation statements)

References 26 publications

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“…It could be argued that there is a potential for a circle definition, since screening is mainly conducted in patients who have been abroad. However, it should be noted that CPE are frequently detected in ESBL-screening, which is done frequently in patients without recent travel history, and there are recent studies to suggest that there are no reservoirs of carbapenem resistance in the Swedish community (Kwak et al, 2015;Ny et al, 2015).…”

Section: Antimicrobial Resistancementioning

confidence: 99%

Carbapenemase-producing Enterobacteriaceae in Sweden 2007–2013: Experiences from seven years of systematic surveillance and mandatory reporting

Löfmark

Sjöström

Mäkitalo

et al. 2015

Drug Resistance Updates

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Section: Antimicrobial Resistancementioning

confidence: 99%

Carbapenemase-producing Enterobacteriaceae in Sweden 2007–2013: Experiences from seven years of systematic surveillance and mandatory reporting

Löfmark

Sjöström

Mäkitalo

et al. 2015

Drug Resistance Updates

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“…One of the most pressing challenges is to determine reservoirs and transmission pathways of CPE and other 4 MDR bacteria in order to reduce the risk to public health. Wastewater has repeatedly been described to reflect the current status of antibiotic-resistant bacteria in the population [6,7]. Hospital wastewater (HWW) is reported to serve as an important reservoir of CPE [8], however the correlation between clinical isolates of CPE and CPE isolated from HWW remains unclear [9,10].…”

Section: Introductionmentioning

confidence: 99%

Wastewater is a reservoir for clinically relevant carbapenemase- and 16s rRNA methylase-producing Enterobacteriaceae

Zurfluh

Bagutti²,

Brodmann³

et al. 2017

International Journal of Antimicrobial Agents

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The aim of this study was to evaluate wastewater for carbapenemase-producing Enterobacteriaceae (CPE) and 16S rRNA methylase-producing Gram-negative bacteria (MPB) and to assess their occurrence following wastewater treatment. Wastewater samples were collected between June 2015 and March 2016 in the sewage network of the city of Basel (Switzerland) from sites located before and after influx of wastewater from the hospital into the sewage network. Samples were also obtained from the influent and effluent of the receiving wastewater treatment plant. Samples were screened for CPE and MPB using selective media. Escherichia coli and Klebsiella pneumoniae were typed by multilocus sequence typing (MLST). Carbapenemase and 16S rRNA methylase genes were identified by PCR and sequencing. Resistance profiles were determined by the disk diffusion test and Etest. The occurrence of CPE and MPB was increased downstream of hospital wastewater influx. Of 49 CPE isolates, 9 belonged to OXA-48-producing E. coli clone D:ST38, 7 were OXA-48-producing Citrobacter freundii, and 6 were KPC-2- or OXA-48-producing K. pneumoniae belonging to clonal complex 258. NDM (NDM-1, -5 and -9) and VIM (VIM-1) producers were detected sporadically. MPB included ArmA- and RmtB-producing E. coli and Citrobacter spp. Isolates corresponding to strains from wastewater were detected in the effluent of the treatment plant. Conclusively, CPE and MPB, predominantly OXA-48-producing Enterobacteriaceae, are readily detected in wastewater, survive wastewater treatment and are released into the aquatic environment. OXA-48-producers may represent an emerging threat to public health and environmental integrity.

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“…The conclusion that wastewater treatment plants contribute heavily to AMR in the environment is supported by a number of studies which investigated the occurrence of AMR in wastewater. In one study, 17 municipal wastewater and 6 hospital wastewater samples were collected and E. coli isolates (1326 and 451 isolates for municipal and hospital wastewaters, respectively) were analyzed for antibiotic susceptibility (Kwak et al, 2015). In total, 34% of the isolates from municipal wastewater and 55% of the isolates from hospital wastewater were resistant to at least one antibiotic.…”

Section: Occurrence Of Amr In the Environmentmentioning

confidence: 99%

Antimicrobial Resistance in the Environment

Williams

Stedtfeld

Guo

et al. 2016

Water Environment Research

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This review summarizes important publications from 2015 pertaining to the occurrence of antimicrobial resistance (AMR) in the environment. Emphasis is placed on sources of antibiotic resistance in the aquatic environment including wastewater treatment plants, hospitals, and agriculture, treatment and mitigation techniques, and surveillance and analysis methodologies for characterizing abundance data. As such, this review is organized into the following sections: i) occurrence of AMR in the environment, including surface waters, aquaculture, and wastewater ii) treatment technologies, and iii) technologies for rapid surveillance of AMR, iv) transmission between matrices, v) databases and analysis methods, and vi) gaps in AMR understanding.

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Surveillance of antimicrobial resistance among Escherichia coli in wastewater in Stockholm during 1 year: does it reflect the resistance trends in the society?

Cited by 93 publications

References 26 publications

Carbapenemase-producing Enterobacteriaceae in Sweden 2007–2013: Experiences from seven years of systematic surveillance and mandatory reporting

Carbapenemase-producing Enterobacteriaceae in Sweden 2007–2013: Experiences from seven years of systematic surveillance and mandatory reporting

Wastewater is a reservoir for clinically relevant carbapenemase- and 16s rRNA methylase-producing Enterobacteriaceae

Antimicrobial Resistance in the Environment

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