Surto de histoplasmose em Pedro Leopoldo, Minas Gerais, Brasil

Cury, Geraldo Cunha; Diniz-Filho, Alberto; Cruz, Antônio Gabriel da Costa e; Hobaika, Adriano Bechara de Souza

doi:10.1590/s0037-86822001000500013

Cited by 18 publications

(15 citation statements)

References 7 publications

(9 reference statements)

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“…Em 2.411 necrópsias e 40.848 espécimes excisados cirurgicamente de vários sítios, foram encontrados 15 nódulos contendo H. capsulatum no pulmão 9 . Os trabalhos publicados demonstram que nódulos pulmonares têm como causa freqüente infecção por H. capsulatum, especialmente em locais que coincidem com zona endêmica (RS, RJ, MG, SP), apresentando reatividade cutânea elevada à histoplasmina 4 , isolamento do fungo no solo 10 14 20 e microepidemias relatadas 3 .…”

Section: Discussionunclassified

Histoplasmoma pulmonar no Rio Grande do Sul

Unis

Pêgas

Severo

2005

Rev. Soc. Bras. Med. Trop.

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Foram revisados dezesseis prontuários de pacientes que apresentavam nódulo pulmonar à radiografia de tórax diagnosticados como histoplasmoma através de achado histopatológico demonstrando elementos fúngicos compatíveis com Histoplasma capsulatum var capsulatum no Rio Grande do Sul. Revisada a literatura brasileira. Todos os pacientes eram brancos, nove eram homens, a média de idade foi de 50,8 anos. Seis (37,5%) pacientes tinham história epidemiológica sugestiva de contato com fungo. Os nódulos variaram de 0,7 a 2,7 cm de diâmetro, apresentavam-se como granuloma com necrose caseosa. Doze (75%) pacientes apresentavam nódulo solitário. O histoplasmoma como regra se apresenta como nódulo solitário com até três centímetros de diâmetro em paciente assintomático. O diagnóstico é realizado por exame histopatológico com coloração especial para visualização do fungo, método de Gomori-Grocott com metenamina argêntica. Cultivo ou testes soromicológicos não contribuem para o diagnóstico.

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Section: Discussionunclassified

Histoplasmoma pulmonar no Rio Grande do Sul

Unis

Pêgas

Severo

2005

Rev. Soc. Bras. Med. Trop.

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“…Currently, visitation is accessed by the Touristic activities may favor the dispersion and import of new microbes (Barton, 2006). This could lead to fungal outbreaks including potential pathogenic species and causing tourists innumerous health problems (Cury et al, 2001).…”

Section: Tourism In Lapa Nova Cavementioning

confidence: 99%

“…Cave visitation may cause conidial suspension and expose visitors to possible infection (Ashford et al, 1999;Lyon et al, 2004). Cases of histoplasmosis have been linked with cave visitation in Brazil (Cury et al, 2001). However, many cases are commonly misdiagnosed and treated as bacterial pneumonia, flu or allergy.…”

Section: Tourism In Lapa Nova Cavementioning

confidence: 99%

“…Guides must be advised about the symptoms and risks of histoplasmosis and medical check-ups histoplasmosis has already been recorded in Brazil (Capone et al, 1999;Unis et al, 2005;Guimarães et al, 2006), with cases related with cave visitation (Cury et al, 2001) or contact with bat guano (Oliveira et al, 2006), there are no records of histoplasmosis associated with the study cave or region.…”

Section: Final Considerations For the Touristic Use Of Lapa Nova Cavementioning

confidence: 99%

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Mycological study for a management plan of a neotropical show cave (Brazil)

Taylor¹,

Stoianoff²,

Ferreira³

2013

IJS

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Caves are stable environments with characteristics favoring the development of microorganisms. The allocthonous input of organic matter and microbes into the warm Neotropical caves may favor the development of filamentous fungi, including pathogenic species. Histoplasma capsulatum is a pathogenic species commonly found in caves and associated with bat and bird guano. Many Brazilian caves have been historically visited due to scenic and religious tourism. The objective of this study was to perform a microbiology study for a management plan of a show cave in Brazil, focusing on the presence and distribution of pathogenic and opportunistic fungi in the cave. Statistic analysis was used to verify the influence of touristic activity on airborne fungi spore load. Fungi were isolated from air and guano in Lapa Nova Cave. Samples were obtained through serial dilution, direct and settle plate techniques. For H. capsulatum, samples were incubated in specific media and conditions. Airborne fungal spore load was compared prior and during visitation and statistically analyzed. A total of 2,575 isolates from the genera Aspergillus, Calcarisporium, Chaetomium, Cladosporium, Curvularia, Emericella, Eurotium, Fusarium, Geotrichum, Gliocladium, Mucor, Purpureocillium, Paecilomyces, Penicillium, Rhizopus and Trichoderma were identified. Histoplasma capsulatum was not isolated from the cave. Eleven opportunistic species were identified. Significant (p<0.05) variations on fungal richness in the air occurred due to cave visitation. Areas of potential microbiologic risks were indicated and management actions suggested. The results suggest a diverse community inhabiting the cave. Possible opportunistic species should be monitored in show caves and microbiota should always be included in the elaboration of cave management plans. This is the first detailed microbiologic study for a management plan of a show cave in the country. It provides relevant information for future management plans

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“…Histoplasmosis is caused by the fungus Histoplasma capsulatum, developing as an acute pulmonary infection of controlled seriousness in healthy individuals and can develop in immunocompromised patients in chronic, progressive or disseminated forms 1 . It is acquired through the inhalation of soil dust particles contaminated by birds and bats feces, containing microconidia (infectious form).…”

Section: Introductionmentioning

confidence: 99%

Clinical and evolutionary characteristics of four patients with pulmonary histoplasmosis reported in the Paraíba Paulista Valley region

Zöllner

Rezende

Birman

et al. 2010

Rev. Soc. Bras. Med. Trop.

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The type of pulmonary histoplasmosis presents limited lesions to the lungs, with symptoms that are clinically and radiological similar to chronic pulmonary tuberculosis. This paper describes the clinical features of four cases of pulmonary histoplasmosis. Aspects of diagnostic and clinical, epidemiological, laboratorial and imaging exams are discussed, in addition to the clinical status of the individuals five years after disease onset. The treatment of choice was oral medication, following which all the patients improved. It is important to understand the clinical status and the difficulties concerning the differential diagnosis of histoplasmosis, to assist the proper indication of cases, thus reducing potential confusion with other diseases.

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Surto de histoplasmose em Pedro Leopoldo, Minas Gerais, Brasil

Cited by 18 publications

References 7 publications

Histoplasmoma pulmonar no Rio Grande do Sul

Histoplasmoma pulmonar no Rio Grande do Sul

Mycological study for a management plan of a neotropical show cave (Brazil)

Clinical and evolutionary characteristics of four patients with pulmonary histoplasmosis reported in the Paraíba Paulista Valley region

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