Surgical treatment of Stages IB and IIA invasive carcinoma of the cervix by radical abdominal hysterectomy

Sall, Sanford; Pineda, Albert; Calanog, Antonio; Heller, Paul B.; Greenberg, Harvey

doi:10.1016/0002-9378(79)90427-7

Cited by 47 publications

(9 citation statements)

References 8 publications

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“…They found no significant difference in overall survival and disease free survival between the two groups; however, the study found increased morbidity in patients who were treated with a combination of surgery and radiotherapy [12]. Some surgeons recommend aborting the radical hysterectomy if frozen section analysis of the pelvic or aortic lymph nodes is positive for disease, as this is an indication for radiation [9]. However, others argue that removal of bulky disease is also important, and that the increased morbidity of the combination of surgery and radiation will have already been incurred with the retroperitoneal lymph node dissection.…”

Section: Combination Treatment For Stage Ib2 and Bulky Iia Cervical Cmentioning

confidence: 95%

“…In the past, radiation therapy alone was considered the standard treatment of LACCA. This changed in 1999 when the National Cancer Institute found that there was a statistically significant survival benefit in the addition of concurrent cisplatinum based chemotherapy to radiotherapy when compared to radiation therapy alone [9]. This announcement came after the review of five randomized co-operative group studies (Table 2) which concluded that the addition of cisplatin to radiotherapy reduces the relative risk of death, local failure rates, and incidence of distant metastases from locally advanced cervical cancer.…”

Section: Locally Advanced Cervical Cancer (Iib-iva)mentioning

confidence: 97%

“…The surgical management for stage IB2 or IIA cervical cancer is a primary abdominal radical hysterectomy with pelvic lymph node dissection and para-aortic lymph node sampling [9]. The operation entails removal of the uterus, parametria and paracervical tissues, the upper 2 cm of the vagina, and the pelvic lymph nodes.…”

Section: Definitive Surgical Therapy For Stage Ib2 and Bulky Iia Cervmentioning

confidence: 99%

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Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Rodriguez

Ryu

et al. 2008

Oncol Rev

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Cervical cancer is one of the most common cancers affecting women, with most early disease treated with either surgery or radiation alone with an 85%-95% 5-year survival rate, while locally advanced cervical cancer (LACCA) requires multiple therapeutic modalities. The clear distinction between early and LACCA has, in recent years, blurred as stages IB2 and bulky IIA, which were traditionally thought of as early disease, have been shown to require more treatment than other early stage cervical cancer. LACC is now treated with cisplatin-based chemoradiation therapy based upon the results of the randomized co-operative group studies that demonstrated reduced relative risk of death, local failure rates, and incidence of distant metastases. Recurrent cervical cancer is devastating and is rarely cured. Treatment of recurrent cervical carcinoma depends on the previous therapy, the site of recurrence, and the extent of the recurrence. This review will outline the treatment options for the various stages of cervical cancer.

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Section: Combination Treatment For Stage Ib2 and Bulky Iia Cervical Cmentioning

confidence: 95%

Section: Locally Advanced Cervical Cancer (Iib-iva)mentioning

confidence: 97%

Section: Definitive Surgical Therapy For Stage Ib2 and Bulky Iia Cervmentioning

confidence: 99%

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Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Rodriguez

Ryu

et al. 2008

Oncol Rev

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“…The efficacy of antibiotic prophylaxis in reducing the frequency of postoperative infections in such patients has been established (2,4). In the 1970s estimates from studies compiling various complications after radical abdominal hysterectomy with bilateral pelvic lymphadenectomy (RHPL) showed that surgical site-related infections occurred in 11% (5,6) to 24% (7) of the RHPL patients. Recent prospective studies showed that a higher percentage of patients not given antibiotic prophylaxis developed infections (8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Infection after radical abdominal hysterectomy and pelvic lymphadenectomy: prevention of infection with a two-dose peri-operative antibiotic prophylaxis

Bouma¹,

Dankert

1993

Int J Gynecol Cancer

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Surgical site‐related infections occurred in 21% of 87 consecutive patients undergoing radical hysterectomy with pelvic lymphadenectomy (RHPL) without planned peri‐operative prophylaxis. A prospective, randomized double‐blind, placebo‐controlled study was conducted in 68 consecutive RHPL patients. In the 32 available patients with two‐dose cefuroxime and metronidazole prophylaxis no surgical site‐related infections developed as opposed to a rate of 14% in the 28 patients in the placebo group (P < 0.05). In a prospective, randomized double‐blind study two two‐dose antibiotic prophylactic regimens were compared in 105 consecutive patients. Surgical site‐related infections developed in one (2%) patient in the cefuroxime plus metronidazole group, and in six (12%) patients in the moxalactam group. This difference did not achieve statistical significance. The mean length of the postoperative hospital stay of the patients with scheduled surgical prophylaxis was significantly shorter (P < 0.01) than that of the patients operated on without surgical prophylaxis. A two‐dose antibiotic regimen is recommended, because levels of antibiotics assayed in samples collected during the course of the operation indicated a rapid clearance of the antibiotics from the operative site, most likely due to the high volume of peri‐operative blood loss.

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“…These findings would be consistent with lymph drainage via the grcatcr omcntum.DiscussionPelvic lymphocyst is a surgical complication related to pelvic lymphadenectomy in gynaecological or urological malignancy(Rutledge et ul. 1959; Choo ef d. 1986) which has been reported to occur after 1-3% of radical hysterectomies(Sall et a/. 1979: Powell et a/.…”

mentioning

confidence: 99%

The use of a functioning omental flap to drain a recurrent pelvic lymphocyst after radical hysterectomy. Case report

Henry

Crandon

1988

BJOG

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Surgical treatment of Stages IB and IIA invasive carcinoma of the cervix by radical abdominal hysterectomy

Cited by 47 publications

References 8 publications

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Infection after radical abdominal hysterectomy and pelvic lymphadenectomy: prevention of infection with a two-dose peri-operative antibiotic prophylaxis

The use of a functioning omental flap to drain a recurrent pelvic lymphocyst after radical hysterectomy. Case report

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