Surgical Treatment of Lung Metastases of Colorectal Carcinoma – Survival and Prognostic Factors

Dzian, Anton; Uhnák, Marek; Hamžík, J

doi:10.14735/amko2015345

Cited by 3 publications

(1 citation statement)

References 12 publications

(18 reference statements)

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“…His survival is comparable to the longest median survival reported in the literature. Our case and the recent literature appears to support a more aggressive approach to treatment of patients who have HCC and lung metastases, since outcomes are comparable to results with resection of lung metastases in colorectal cancer [ 9 , 10 , 11 ]. It is our impression that practitioners in the United States and Europe may be less aware of this literature.…”

Section: Discussionsupporting

confidence: 71%

Long-Term Survival after Resection of Lung Metastases from Hepatocellular Cancer: Report of a Case and Review of the Literature

et al. 2016

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Hepatocellular cancer (HCC) is increasing dramatically in incidence in Europe and the United States due mainly to the hepatitis C epidemic and, to a lesser extent, increased body mass index of the population. In the fairly recent past, HCC was largely considered as untreatable due to detection mainly at late stages and lack of effective drugs for treatment. Several advances have led to changes in the prognosis of HCC. Screening of high-risk populations has allowed for earlier detection in some studies. If found at an early stage, liver transplantation not only cures the usual underlying cirrhosis but has cure rates for HCC in the range of 60% in recent series. Larger lesions can sometimes be cured by partial hepatic resection assuming the remaining liver is not too damaged to sustain liver functions after surgery. Vaccination for hepatitis B has led to reduction in the incidence of HCC. Significant improvements in antiviral treatments for both hepatitis B and hepatitis C may be having an impact on the incidence of HCC as well. It is still generally held that a finding of metastases precludes cure of HCC. We here report the case of a patient who presented with a large HCC in the context of occult hepatitis C infection. The primary tumor was resected. Over a year later, he developed a lung metastasis that was resected as well. He has not shown recurrence for 6 years since the metastasectomy. We review the recent literature on resection of lung metastases from HCC.

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Section: Discussionsupporting

confidence: 71%

Long-Term Survival after Resection of Lung Metastases from Hepatocellular Cancer: Report of a Case and Review of the Literature

et al. 2016

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Microbial HSP70 peptide epitope 407–426 as adjuvant in tumor-derived autophagosome vaccine therapy of mouse lung cancer

Xing

Zhou

et al. 2016

Tumor Biol.

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Tumor-derived autophagome (DRibble) is an effective therapeutic cancer vaccine inducing T cell recognition and death of tumor cells in mice. However, the potential for improved anti-tumor response still remains. Our previous study demonstrated that two repeats of a mycobacterial HSP70 (M2) peptide acted as adjuvant in improving anti-tumor efficacy of human umbilical vein endothelial cell (HUVEC) vaccine. Here, a DRibble vaccine conjugated with M2 (DRibble-M2) was designed as a novel vaccine to enhance anti-tumor activity. Compared with DRibble alone, DRibble-M2 vaccination more significantly inhibited the growth of mouse Lewis lung cancer both in a subcutaneous tumor model and in a lung metastasis model. Higher expression of antigen-specific CTL was induced by DRibble-M2. DRibble-M2 induced higher CD83 and CD86 expression in DC2.4 and also improved the internalization of DRibble antigen into DC2.4. Our data indicated that DRibble-M2 is a potential vaccine for clinical cancer therapy.

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WITHDRAWN: Diagnostic performance of MASP-2 in the diagnosis of colorectal carcinoma

Zhang

Mao

et al. 2020

Pathology - Research and Practice

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Surgical Treatment of Lung Metastases of Colorectal Carcinoma – Survival and Prognostic Factors

Cited by 3 publications

References 12 publications

Long-Term Survival after Resection of Lung Metastases from Hepatocellular Cancer: Report of a Case and Review of the Literature

Long-Term Survival after Resection of Lung Metastases from Hepatocellular Cancer: Report of a Case and Review of the Literature

Microbial HSP70 peptide epitope 407–426 as adjuvant in tumor-derived autophagosome vaccine therapy of mouse lung cancer

WITHDRAWN: Diagnostic performance of MASP-2 in the diagnosis of colorectal carcinoma

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