Surgical treatment of complicated colorectal cancer: tactical aspects (a literature review)

Щаева, С. Н.

doi:10.17650/2220-3478-2017-7-1-57-68

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Sometimes it outweighs the primary operation and is characterized by a relatively high incidence of complications, which is more associated with the development of adhesive disease. Moreover, the adhesion process often leads to significant technical difficulties when performing repeated operations on the abdominal organs, while increasing the number of surgical complications (Lutsevich et al, 2007;Shchaeva, 2017;Banerjee et al, 2005;Dalgic et al, 2015).…”

Section: Research Articlementioning

confidence: 99%

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

Zhakipbekov

Osombaev

Irimbetov

2022

Asian Pac J Cancer Prev

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Objective: The aim of this study was to improve the direct results of reconstructive surgery in patients operated on for complicated forms of colorectal cancer, by using 5-fluorouracil in the postoperative period. Methods: The study involved 126 patients (they were divided into 2 groups) with colorectal cancer, who underwent reconstructive surgery. They underwent a standard clinical examination and a mandatory examination program. Results: The use of 5-fluorouracil in adjuvant treatment in patients with colorectal cancer significantly reduces the number of subjective clinical manifestations (positional tests) in the main group – 17%, and in the control group – 54.3%, as well as objective clinical manifestations (instrumental research methods) in Group I – 13%, and Group II – 89.5%, respectively. The study shows that in re-operated patients with colorectal cancer who received 5-fluorouracil, abdominal adhesions are characterized by a low content of collagen and fibroblasts, low vascularization and a high content of polymerized fibrin strands. It was also found that re-operated patients with colorectal cancer who did not receive 5-fluorouracil, abdominal adhesions are characterized by a high collagen content, a large number of fibroblasts, and severe angiogenesis. Conclusion: It was found that the prolonged administration of 5-fluorouracil statistically significantly reduces the risk of adhesions, thereby showing the effectiveness of preventing adhesive disease of the abdominal organs. It was shown that the prolonged administration of 5-fluorouracil significantly reduces the number of subjective and objective signs of adhesive disease of the abdominal organs, as well as significantly decreases intraoperative and postoperative complications, the duration of the operation, and the amount of blood loss. In the postoperative period, it reduces the length of hospital stay and improves the quality of life of patients.

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Section: Research Articlementioning

confidence: 99%

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

Zhakipbekov

Osombaev

Irimbetov

2022

Asian Pac J Cancer Prev

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Evolution of enhanced recovery after surgery: from the beginning of the study of stress to the introduction in emergency surgery

Sizonenko

Surov

Соловьев

et al. 2018

Khir. Z. im. N.I. Pirogova

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A model for predicting outcomes of primary resection with colostomy in patients with acute colonic cancer obstruction

Корымасов

Fesyun

Krivoshchekov

et al. 2023

Science and Innovations in Medicine

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Aim to create a model for predicting outcomes of resection with colostomy in patients with acute obturation colon obstruction caused by tumor. Material and methods.The study design was a retrospective multicenter analysis for the period from 2013 to 2020. At the first stage, we analyzed 3854 medical records of patients who were subject to emergent surgery in the surgical departments of the Samara region for acute colonic cancer obstruction, with tumor localized in the colon. We compared the outcomes of colon primary resection for tumor removal followed by colostomy and surgical treatment with colostomy without resection. At the second stage, we analyzed the complications risk factors in patients with colon primary resection for tumor removal followed by a single-barrel colostomy, n = 1936. Results.According to the study, the active surgical intervention had no statistically significant correlation to the increase in number of adverse outcomes. We identified the statistically significant risk factors for an unfavorable outcome after primary intestinal resection. These data allowed us to create and register a soft-ware "Automated system for determining the risk of primary intestinal resection in case of colonic cancer obstruction". The next stage of the study was planned for validation of the developed risk-predicting model, in patients being consistently admitted to on-duty surgical departments. Conclusion.The choice of the method of surgery for tumor colonic obstruction is preconditioned by the basic requirement the resolution of intestinal obstruction. In a number of cases, the primary resection of the intestine with a tumor and with the single-barrel colostomy can be performed. If it is possible to perform primary intestinal resection on the basis of traditional principles, the risk of its implementation should be assessed for postoperative complications using a standard method. At present, the standard method does not exist in clinical recommendations and requires development and implementation.

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Surgical treatment of complicated colorectal cancer: tactical aspects (a literature review)

Cited by 3 publications

References 38 publications

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer

Evolution of enhanced recovery after surgery: from the beginning of the study of stress to the introduction in emergency surgery

A model for predicting outcomes of primary resection with colostomy in patients with acute colonic cancer obstruction

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