Surgical results of skull base surgery for the treatment of head and neck malignancies involving skull base: multi-institutional studies on 143 cases in Japan

Fukuda, Satoshi; Sakai, Noboru; Kamata, Shinkichi; Nameki, Hideo; Kishimoto, Seiji; Nishikawa, Kunio; Kaneko, Shozo; Miyata, Mamoru; Fujisawa, Masato; Inuyama, Yukio

doi:10.1016/s0385-8146(01)00083-9

Cited by 21 publications

(12 citation statements)

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“…The incidence of surgery-related complications in our series was comparable to other studies [12,28,34]. Fukuda et al [12] observed postoperative complications in 62 out of 143 cases of their large, multiinstitutional study on surgical results of skull base surgery for the treatment of head and neck malignancies involving the base of the skull.…”

Section: Discussionsupporting

confidence: 88%

“…Fukuda et al [12] observed postoperative complications in 62 out of 143 cases of their large, multiinstitutional study on surgical results of skull base surgery for the treatment of head and neck malignancies involving the base of the skull. In their study, local infection was the most frequent complication (29/62); meningitis was diagnosed in ten cases, and liquorrhea occurred in 18/62 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Despite significant advances in cranial base surgery [9,12] and radiation therapy [1,5,6,11,27,29,[35][36][37], complete tumor eradication of advanced skull base tumors is still often impossible. Even after mutilating tumor surgery including enucleation, tumor recurrence of advanced carcinomas occurs.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

et al. 2005

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Perioperative fractionated IMBT after extensive but vision-preserving tumor resection seems to be a safe and well-tolerated treatment of advanced/recurrent malignancies involving the skull base. These preliminary data suggest that combined operation and perioperative fractionated IMBT is a palliative therapeutic option in the management of fatal malignancies involving the base of the skull, a strategy which leaves the patients' visual acuity intact.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

et al. 2005

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“…[15] We find that wherever we have used the galeofrontalis flap there has been a high incidence of skin changes if the patient has been radiated postoperative [Figure 3]. We have had frontal bone osteoradionecrosis in 12 patients.…”

Section: Infectionmentioning

confidence: 99%

“…Its use has completely stopped the incidence of further central defect leaks. [1519] Excessive use of this flap has also led to an increase in the incidence of radiation damage to the bone and skin in the frontal area which takes about 9-12 months to settle down or may require the bone to be debrided as mentioned earlier. [3]…”

Section: Hemorrhagementioning

confidence: 99%

Unfavourable results in skull base surgery

Jaju¹

2013

Indian J Plast Surg

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Treatment of skull base tumors involves multiple specialities. The lesions are usually advanced and the treatment is often associated with unfavorable results, which may be functional and/or aesthetic. Here we have done an analysis for the complications and unfavorable results of 546 cases treated surgically by a single craniofacial surgeon over a period of 14 years. The major morbidity ranges from death to permanent impairment of vital organ functions (brain, eye, nose), infections, tissue losses, flap failures, treatment associated complications, psychosocial issues, and aesthesis besides others. This article is aimed at bringing forth these unfavorable results and how to avoid them.

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Craniofacial surgery for malignant skull base tumors

Patel

Singh

Polluri

et al. 2003

Cancer

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312

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BACKGROUND. Malignant tumors of the skull base are rare. Therefore, no single center treats enough patients to accumulate significant numbers for meaningful analysis of outcomes after craniofacial surgery (CFS). The current report was based on a large cohort that was analyzed retrospectively by an International Collaborative Study Group. METHODS. One thousand three hundred seven patients who underwent CFS in 17 institutions were analyzable for outcome. The median age was 54 years (range, 1-98 years). Definitive treatment prior to CFS had been administered in 59% of patients and included radiotherapy in 367 patients (28%), chemotherapy in 151 patients (12%), and surgery in 523 patients (40%). The majority of tumors (87%) involved the anterior cranial fossa. Squamous cell carcinoma (29%) and adenocarcinoma (16%) were the most common histologic types. The margins of surgical resection were reported close/positive in 412 patients (32%). Adjuvant postoperative radiotherapy was received by 510 patients (39%), and chemotherapy was received by 57 patients (4%). RESULTS. Postoperative complications were reported in 433 patients (33%), with local wound complications the most common (18%). The postoperative mortality rate was 4%. With a median follow-up of 25 months, the 5-year overall, diseasespecific, and recurrence-free survival rates were 54%, 60%, and 53%, respectively. The histology of the primary tumor, its intracranial extent, and the status of surgical margins were independent predictors of overall, disease-specific, and recurrence-free survival on multivariate analysis. CONCLUSIONS. CFS is a safe and effective treatment option for patients with malignant tumors of the skull base. The histology of the primary tumor, its intracranial extent, and the status of surgical margins are independent determi

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Surgical results of skull base surgery for the treatment of head and neck malignancies involving skull base: multi-institutional studies on 143 cases in Japan

Cited by 21 publications

References 1 publication

Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

Unfavourable results in skull base surgery

Craniofacial surgery for malignant skull base tumors

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