Surgical resection versus liver transplant for patients with hepatocellular carcinoma

Abstract

There are no randomised clinical trials comparing surgical resection and liver transplantation for hepatocellular carcinoma treatment.

Liver transplantation versus liver resection for hepatocellular carcinoma in intention to treat: An attempt to perform an ideal meta‐analysis

“…One limit of this analysis was the lack of published RCTs . Moreover, to our knowledge, no RCT comparing LR with LT is ongoing or registered at https://clinicaltrials.gov.…”

Liver transplantation versus liver resection for hepatocellular carcinoma in intention to treat: An attempt to perform an ideal meta‐analysis

“…One limit of this analysis was the lack of published RCTs . Moreover, to our knowledge, no RCT comparing LR with LT is ongoing or registered at https://clinicaltrials.gov.…”

The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives

“…Only this type of study holds that patients in the intervention group would have attained a similar survival to the control group if they were given the control treatment, hereby giving an unbiased representation of the treatment effect. Nevertheless, the Cochrane review by Taefi et al (2013) focused on RCTs, concluded that none were performed [39]. Furthermore, no studies are currently registered at clinicaltrials.gov (accessed on 16 July 2021).…”

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

“…Partial hepatectomy (PH) is an alternative to liver transplantation as it induces hepatic regeneration and repopulation of the damaged liver with healthy hepatocytes. Despite the lack of randomized clinical trials comparing PH and liver transplant, PH circumvents organ shortage and long waiting periods associated with disease progression, being highly relevant for hepatocellular carcinoma patients . According to the scientific registry of transplant recipients, NASH‐related cirrhosis is currently the third most common indication for liver transplantation in the United States, surpassed only by hepatitis C virus and alcohol‐related cirrhosis.…”

Liver transplantation versus liver resection for hepatocellular carcinoma in intention to treat: An attempt to perform an ideal meta‐analysis

“…One limit of this analysis was the lack of published RCTs . Moreover, to our knowledge, no RCT comparing LR with LT is ongoing or registered at https://clinicaltrials.gov.…”

The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives

“…Only this type of study holds that patients in the intervention group would have attained a similar survival to the control group if they were given the control treatment, hereby giving an unbiased representation of the treatment effect. Nevertheless, the Cochrane review by Taefi et al (2013) focused on RCTs, concluded that none were performed [39]. Furthermore, no studies are currently registered at clinicaltrials.gov (accessed on 16 July 2021).…”

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

“…Partial hepatectomy (PH) is an alternative to liver transplantation as it induces hepatic regeneration and repopulation of the damaged liver with healthy hepatocytes. Despite the lack of randomized clinical trials comparing PH and liver transplant, PH circumvents organ shortage and long waiting periods associated with disease progression, being highly relevant for hepatocellular carcinoma patients . According to the scientific registry of transplant recipients, NASH‐related cirrhosis is currently the third most common indication for liver transplantation in the United States, surpassed only by hepatitis C virus and alcohol‐related cirrhosis.…”

Liver transplantation versus liver resection for hepatocellular carcinoma in intention to treat: An attempt to perform an ideal meta‐analysis

“…One limit of this analysis was the lack of published RCTs . Moreover, to our knowledge, no RCT comparing LR with LT is ongoing or registered at https://clinicaltrials.gov.…”

The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives

“…Only this type of study holds that patients in the intervention group would have attained a similar survival to the control group if they were given the control treatment, hereby giving an unbiased representation of the treatment effect. Nevertheless, the Cochrane review by Taefi et al (2013) focused on RCTs, concluded that none were performed [39]. Furthermore, no studies are currently registered at clinicaltrials.gov (accessed on 16 July 2021).…”

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

“…Partial hepatectomy (PH) is an alternative to liver transplantation as it induces hepatic regeneration and repopulation of the damaged liver with healthy hepatocytes. Despite the lack of randomized clinical trials comparing PH and liver transplant, PH circumvents organ shortage and long waiting periods associated with disease progression, being highly relevant for hepatocellular carcinoma patients . According to the scientific registry of transplant recipients, NASH‐related cirrhosis is currently the third most common indication for liver transplantation in the United States, surpassed only by hepatitis C virus and alcohol‐related cirrhosis.…”