Surgical resection, intraoperative radiotherapy and immediate plastic reconstruction: A good option for the treatment of distal extremity soft tissue sarcomas

Hanna, Samir Abdallah; Munhoz, Rodrigo Ramella; Perina, André Luis de Freitas; Gonçalves, Marina Sahade; Costa, Fabio Paganini Pereira da; Busnardo, Fábio de Freitas; Ferreira, Fábio de Oliveira

doi:10.1016/j.rpor.2020.09.008

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…This could also be associated with greater awareness of the condition, earlier detection and surgical excision, or new treatment options. including intraoperative radiotherapy, which has shown to promote limb preservation [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and survival factors of appendicular myxofibrosarcoma: a SEER-retrospective study

Dahl,

Yonghoon,

Rate IV

et al. 2023

Rep Pract Oncol Radiother.

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Background The low incidence of myxofibrosarcoma (MFS) makes high power studies difficult to perform. Demographic and prognostic factors for MFS and how they differ from all extremity soft tissue sarcomas (STS) are not well understood. The purpose of this study was to characterize a large cohort of patients with MFS and evaluate epidemiologic and survival factors when compared to all STS. Materials and methods We performed a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2015 to identify 1,440 patients diagnosed with MFS and 12,324 with STS. Survival curves were creased using Kaplan-Meier, and Cox regression analyses were performed to identify hazard ratios (HRs). Results Overall survival was greater for STS than MFS (79% vs . 67%). Patients with MFS had a higher average age at diagnosis than STS (62 vs . 56), and older age was strongly associated with decreased survivorship for MFS (HR = 7.94). A greater proportion of patients under 30 diagnosed with MFS were female when compared to STS (49.6% vs . 45.4%). The incidence of MFS and STS increased over the 15-year period, with MFS increasing at a greater rate than STS (1.25% vs . 2.59%). Survival increased for patients diagnosed after 2008 for both STS (9.4%) and MFS (13.2%). Conclusions There are differences between patient demographics and survival factors when comparing MFS to all STS. Monitoring changes in demographic and survival trends for rare STS subtypes like MFS is important to improve diagnostic algorithms and treatment options.

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Section: Discussionmentioning

confidence: 99%

Epidemiology and survival factors of appendicular myxofibrosarcoma: a SEER-retrospective study

Dahl,

Yonghoon,

Rate IV

et al. 2023

Rep Pract Oncol Radiother.

View full text Add to dashboard Cite

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“…[2] The main axis of treatment for STSs is wide resection, and chemotherapy and radiotherapy are useful adjuvant treatments. [3,4] Although pazopanib, trabectedin, and eribulin have been approved for the treatment of high-grade STSs recently, their efficacy is not sufficient. [5][6][7] However, the prognosis of patients with STSs has reached approximately 65% for 5-year survival, and the prognosis of high-grade STSs or younger patients with STSs is slightly less than that.…”

Section: Introductionmentioning

confidence: 99%

Characterizing inflammatory markers in highly aggressive soft tissue sarcomas

et al. 2022

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The prognosis for soft tissue sarcomas (STSs) is poor, especially for highly aggressive STSs, and the details of prognostic factors are unknown. This study aimed to investigate the prognostic factors for STSs in hematologic inflammatory markers. We included 22 patients with STSs treated at our institution. The STSs were histologically classified as follows: undifferentiated pleomorphic sarcoma, 7 cases; myxofibrosarcoma, 6 cases; and malignant peripheral nerve sheath tumor, 2 cases. The average patient age was 72.06 years. The numbers of patients who underwent each procedure were as follows: wide resection, 7; wide resection and flap, 2; marginal resection, 2; wide resection and radiation, 1; additional wide resection with flap, 1; wide resection and skin graft, 1; and radiotherapy only, 1. The median follow-up period was 26 months (3–92 months). The outcomes were as follows: continuous disease free, 6 cases; no evidence of disease, 6 cases; alive with disease, 1 case; and died of disease, 2 cases. Pretreatment blood examinations for C-reactive protein (CRP) and albumin levels; neutrophil, lymphocyte, and white blood cell (WBC) counts; and neutrophil/lymphocyte (N/L) ratio were investigated and correlated with tumor size, tissue grade, and maximum standardized uptake value (SUVmax). CRP level and neutrophil and WBC counts were positively correlated with tissue grade and SUVmax. N/L ratio was positively correlated with tumor size and SUVmax. CRP level, WBC and neutrophil counts, and N/L ratio may be poor prognostic factors for highly aggressive STSs.

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Surgical resection, intraoperative radiotherapy and immediate plastic reconstruction: A good option for the treatment of distal extremity soft tissue sarcomas

Cited by 2 publications

References 53 publications

Epidemiology and survival factors of appendicular myxofibrosarcoma: a SEER-retrospective study

Epidemiology and survival factors of appendicular myxofibrosarcoma: a SEER-retrospective study

Characterizing inflammatory markers in highly aggressive soft tissue sarcomas

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