Surgical Pathology of Colorectal Cancer in Filipinos: Implications for Clinical Practice1

Kaw, Leoncio L.; Punzalan, Corazon K; Crisostomo, Armando C.; Bowyer, Mark W.; Wherry, David C.

doi:10.1016/s1072-7515(02)01186-9

Cited by 17 publications

(13 citation statements)

References 35 publications

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“…The average age of patients with sporadic CRC is close to 70 years although about 6-17% of patients develop the disease at a younger age [4,5]. There are substantial clinicalpathological and molecular differences in the presentation of CRC in the younger age group when compared to the older age group.…”

Section: Introductionmentioning

confidence: 99%

Young-age onset of colorectal cancer in Israel

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Young-age onset of colorectal cancer in Israel

et al. 2009

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“…4 Furthermore, it typically appears in young adults. 5 Macroscopically, PSRCCR shows the characteristic appearance of linitis plastica, as a shrunken, rigid structure. [1][2][3][4][5] Histologically, the neoplastic cells resemble signet rings because they contain abundant intracytoplasmic mucin, which pushes the nuclei to the periphery.…”

mentioning

confidence: 99%

“…[1][2][3][4][5] Histologically, the neoplastic cells resemble signet rings because they contain abundant intracytoplasmic mucin, which pushes the nuclei to the periphery. [1][2][3][4][5] The presence of mucus secretion in microscopic examinations of the tumor is one of the most important parameters determining the biologic behavior of colorectal carcinomas; other factors are age, sex, tumor location, tumor diameter, grade, stage, lymphatic and vascular invasion, periserosal overgrowth, and distant metastasis. 6,7 So far, only a limited number of case reports have been published on this subject.…”

mentioning

confidence: 99%

Outcomes of Surgical Treatment of Primary Signet Ring Cell Carcinoma of the Colon and Rectum: 22 Cases Reviewed With Literature

Bellı

Aytaç

Karagülle

et al. 2014

International Surgery

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Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The objective of this study was to investigate the clinicopathologic features and prognostic factors for PSRCCR. This is a retrospective study including the data of 22 patients with PSRCCR who underwent surgery. Patients were categorized by age, sex, tumor site, and stage. Fifteen patients were male. Median age was 40 years. Sites for metastases were lymph nodes (86.4%), peritoneum (40.9%), and liver (9.1%). Most of the patients (91%) had stage III or IV tumors. The rates of curative and palliative resections performed were equal. Mean overall survival and mean progression-free survival times were found to be 33.3 6 7.1 months (95% confidence interval, 19.4-47.2 months) and 11.8 6 3.5 months (95% confidence interval, 4.9-18.7 months), respectively. It was concluded that site of the tumor, presence of bowel obstruction, peritoneum and lung metastases, adjacent organ infiltration, TNM stage, and efficiency of surgery have significant effects on survival. All in all, these aggressive tumors are generally diagnosed at advanced stages. Depending on the situation, survival is shorter. A high degree of vigilance is required for these patients to avoid the negative impact of late diagnosis on survival.

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“…Furthermore, Filipino patients were reported to present unique clinicopathological characteristics, including rare occurrence of polyps [37], and histological findings suggest the possibility of an alternative tumorgenesis pathway [37,38]. This implies more difficulty in CRC detection using endoscopic or radiographic procedures, and that prevention measures through polyp removal may not be applicable.…”

Section: Discussionmentioning

confidence: 99%

“…This implies more difficulty in CRC detection using endoscopic or radiographic procedures, and that prevention measures through polyp removal may not be applicable. Furthermore, the unique pathology in Filipinos indicate that current screening guidelines in Western countries might not be appropriate [37]. Various recommendations for CRC screening have been put forward [39,40], but no program currently exists in the country.…”

Section: Discussionmentioning

confidence: 99%

Inter-country and ethnic variation in colorectal cancer survival: Comparisons between a Philippine population, Filipino-Americans and Caucasians

et al. 2010

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BackgroundPrevious population-based studies showed differences in international and within country colorectal cancer survival estimates, but few investigated the role of prognostic factors. Using a "high resolution approach", we aimed to determine the effect of ethnicity and health care by comparing Filipino-Americans with Philippine residents, who have the same ethnicity, and with Caucasians living in the US, who have the same health care system.MethodsUsing databases from the Manila and Rizal Cancer Registries and the United States Surveillance, Epidemiology and End Results, age-adjusted five-year absolute and relative survival estimates were computed and compared between Filipino-American colorectal cancer patients, cancer patients from the Philippines and Caucasian patients. Cox proportional hazards modelling was used to determine factors affecting survival differences.ResultsMuch lower 5-year relative survival estimates were obtained for Philippine residents (37%) as compared to those in Filipino-Americans (60.3%) and Caucasians (62.4%). Differences in age, stage and receipt of surgery explained a large proportion of the survival differences between Philippine residents and Filipino-Americans. However, strong excess risk of death for Philippine residents remained after controlling for these and other variables (relative risk, RR, 2.03, 95% confidence interval, 95% CI, 1.83-2.25).ConclusionsStrong survival disadvantages of Philippine residents compared to Filipino-American patients were disclosed, which most likely reflect differences in access to and utilization of health care. Health education and advocacy, for both patients and health practitioners, should likewise be given priority.

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Surgical Pathology of Colorectal Cancer in Filipinos: Implications for Clinical Practice1

Cited by 17 publications

References 35 publications

Young-age onset of colorectal cancer in Israel

Young-age onset of colorectal cancer in Israel

Outcomes of Surgical Treatment of Primary Signet Ring Cell Carcinoma of the Colon and Rectum: 22 Cases Reviewed With Literature

Inter-country and ethnic variation in colorectal cancer survival: Comparisons between a Philippine population, Filipino-Americans and Caucasians

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