Surgical Diseases of the Liver.

Abstract

The first half of the symposium is devoted to a con¬ sideration of the nature and functions of factor VIII (AHF) and factor IX (PTC). With as much sim¬ plicity as the complexity of the subject matter permits, the participants address themselves to méthodologie problems involved in standardization, assay and purifi¬ cation of these factors; to their biochemistry and metabolic fate ; and to their role in coagulation kinetics. Not only is a voluminous and scattered literature sum¬ marized, but gaps in our knowledge are highlighted and informed speculation on future work is presented.

Hepatocytes

“…and, more importantly, drugs. Hence, hepatocyte function strongly impacts on the pharmacokinetics, side effects, and toxicity of drugs (1,2).…”

Effect of preoperative interventions on outcome following liver resection in a rat model of cirrhosis

“…While this is a quick and simple test which provides useful prognostic data clinically [48], both ciprofloxacin and pentoxifylline may affect the PT and lead to deceiving estimates of liver function [193]. In the case of ciprofloxacin, this and other antibiotics have been documented to alter the bacterial flora and decrease vitamin K absorption, leading to an increased PT with prolonged use [193].…”

Chronic hepatitis A: An historical note

“…When these stools (20% suspension) were inoculated separately into two groups of four prisoner volunteers, one member of each group developed hepatitis with jaundice 22 and 26 days, respectively, after inoculation. On the basis of this experience, the presence of both chronic hepatitis A and chronic fecal excretion of hepatitis A virus were postulated.While at least three recent textbooks on liver disease [Schiff and Schiff, 1982;Sherlock, 1981; Wright et al, 19791 state that chronicity and a carrier state do not occur in hepatitis A, and though no other evidence to the contrary has been presented since 1954, there remains the nagging question of whether these children were, in spite of all the evidence in later studies, truly chronically infected with hepatitis A virus. Indeed, reference was made to the 1954 experiments as recently as March, 1984 (International Symposium on Viral Hepatitis, San Francisco, CA).…”