volume 80, issue 1, P245-257 2021
DOI: 10.3233/jad-201232
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Zhongmeng Lai, Jia Min, Jun Li, Weiran Shan, Weifeng Yu, Zhiyi Zuo

Abstract: Background: Perioperative, modifiable factors contributing to perioperative neurocognitive disorders (PND) have not been clearly defined. Objective: To determine the contribution of anesthesia lengths and the degrees of surgical trauma to PND and neuroinflammation, a critical process for PND. Methods: Three-month-old C57BL/6J mice were subjected to 2 h or 6 h isoflurane anesthesia plus a 5 min or 15 min left common carotid artery exposure (surgery) in a factorial design (two factors: anesthesia with two levels…

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