Surgery for cervical intraepithelial neoplasia

Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis

“…Our results for treatment failure were consistent in secondary analyses using various cutoffs for definition of treatment failure and for high-risk HPV positivity rates at 6 months. Our findings are in contrast with those of a Cochrane meta-analysis of randomised controlled trials that found no difference in efficacy among different CIN treatments, 14 probably due to the small number of studies included in each pairwise comparison. In subgroup analyses, we found that CKC was more effective than LLETZ for treatment of endocervical lesions (post hoc) and when done in older (median age of ≥33 years) women (prespecified).…”

Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis

“…Our results for treatment failure were consistent in secondary analyses using various cutoffs for definition of treatment failure and for high-risk HPV positivity rates at 6 months. Our findings are in contrast with those of a Cochrane meta-analysis of randomised controlled trials that found no difference in efficacy among different CIN treatments, 14 probably due to the small number of studies included in each pairwise comparison. In subgroup analyses, we found that CKC was more effective than LLETZ for treatment of endocervical lesions (post hoc) and when done in older (median age of ≥33 years) women (prespecified).…”

Efficacy, acceptability and safety of ablative versus excisional procedure in the treatment of histologically confirmed CIN2/3: A systematic review

“…Many of the included studies used VIA or cytology without histology confirmation to ascertain treatment success. A Cochrane review reported the cure rate for CIN3 following LLETZ to range from 91% to 98%, 9 similar to the cure rate observed in our study.…”

Treatment of Cervical Dysplasia by Clinicians Who Perform Colposcopy in German-speaking Countries – a Questionnaire-based Study

“…The preference for this loop also correlates with the number of women with cervical dysplasia examined annually. These data also correspond to the current literature, according to which loop excision is superior to other methods with regard to the long-term complications listed and knife conisation is considered obsolete 31 , 32 , 33 , 34 . A recently published and, to date, the only randomised work on the topic “conisation under colposcopic visualisation” additionally comes to the conclusion that conisation performed under colposcopic visualisation leads to the removal of cones with a smaller volume without influencing the resection status 35 .…”

Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis

“…Our results for treatment failure were consistent in secondary analyses using various cutoffs for definition of treatment failure and for high-risk HPV positivity rates at 6 months. Our findings are in contrast with those of a Cochrane meta-analysis of randomised controlled trials that found no difference in efficacy among different CIN treatments, 14 probably due to the small number of studies included in each pairwise comparison. In subgroup analyses, we found that CKC was more effective than LLETZ for treatment of endocervical lesions (post hoc) and when done in older (median age of ≥33 years) women (prespecified).…”

Efficacy, acceptability and safety of ablative versus excisional procedure in the treatment of histologically confirmed CIN2/3: A systematic review

“…Many of the included studies used VIA or cytology without histology confirmation to ascertain treatment success. A Cochrane review reported the cure rate for CIN3 following LLETZ to range from 91% to 98%, 9 similar to the cure rate observed in our study.…”

Treatment of Cervical Dysplasia by Clinicians Who Perform Colposcopy in German-speaking Countries – a Questionnaire-based Study

“…The preference for this loop also correlates with the number of women with cervical dysplasia examined annually. These data also correspond to the current literature, according to which loop excision is superior to other methods with regard to the long-term complications listed and knife conisation is considered obsolete 31 , 32 , 33 , 34 . A recently published and, to date, the only randomised work on the topic “conisation under colposcopic visualisation” additionally comes to the conclusion that conisation performed under colposcopic visualisation leads to the removal of cones with a smaller volume without influencing the resection status 35 .…”

Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis

“…Our results for treatment failure were consistent in secondary analyses using various cutoffs for definition of treatment failure and for high-risk HPV positivity rates at 6 months. Our findings are in contrast with those of a Cochrane meta-analysis of randomised controlled trials that found no difference in efficacy among different CIN treatments, 14 probably due to the small number of studies included in each pairwise comparison. In subgroup analyses, we found that CKC was more effective than LLETZ for treatment of endocervical lesions (post hoc) and when done in older (median age of ≥33 years) women (prespecified).…”

Efficacy, acceptability and safety of ablative versus excisional procedure in the treatment of histologically confirmed CIN2/3: A systematic review

“…Many of the included studies used VIA or cytology without histology confirmation to ascertain treatment success. A Cochrane review reported the cure rate for CIN3 following LLETZ to range from 91% to 98%, 9 similar to the cure rate observed in our study.…”

Treatment of Cervical Dysplasia by Clinicians Who Perform Colposcopy in German-speaking Countries – a Questionnaire-based Study

“…The preference for this loop also correlates with the number of women with cervical dysplasia examined annually. These data also correspond to the current literature, according to which loop excision is superior to other methods with regard to the long-term complications listed and knife conisation is considered obsolete 31 , 32 , 33 , 34 . A recently published and, to date, the only randomised work on the topic “conisation under colposcopic visualisation” additionally comes to the conclusion that conisation performed under colposcopic visualisation leads to the removal of cones with a smaller volume without influencing the resection status 35 .…”