Surfactin reduces particulate matter–induced VCAM‐1–dependent monocyte adhesion in human gingival fibroblasts by increasing Nrf2‐dependent HO‐1 expression

Vo, Thi Thuy Tien; Huang, Hei Jen; Wee, Yinshen; Feng, Sheng-Wei; Cheng, Hsin-Chung; Tuan, Vo Phuoc; Lee, I-Te

doi:10.1111/jre.12944

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Restoring the expression of antioxidant enzymes in DSS-treated mice is one possible mode-of-action of substances that improve IBD [ 46 ]. Although surfactin could induce apoptosis in human oral squamous carcinoma cells through ROS induction [ 47 ], it reduced particulate matter-induced ROS production through up-regulation of HO-1 expression in human gingival fibroblasts [ 48 ]. The effect of SBLF on DSS-induced oxidative stress in mice needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Tsai

Wong

Hsu

et al. 2022

Animals

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Inflammatory bowel disease (IBD) is a non-infectious disease characterized by chronic inflammation of the gastrointestinal tract. Currently, management of IBD is still a clinical challenge. The purpose of this study was to investigate the therapeutic potential of surfactin containing Bacillus licheniformis-fermented products (SBLF) and commercial surfactin (CS) on the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. We found that mice that received drinking water containing 3% DSS developed significant colitis symptoms, including increased disease activity index, body weight loss, shortening of the colon length, splenomegaly, colonic inflammation and colonic NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. Notably, orally received SBLF, CS or clinical anti-inflammatory drug 5-aminosalicylic acid improved DSS-induced colitis symptoms in mice. These findings show that SBLF can improve IBD in mice by reducing colonic inflammation and inhibiting the NLRP3 inflammasome activation, suggesting that SBLF has the potential to be used as a nutraceutical in humans or a feed additive in economic and companion animals for preventing IBD.

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Section: Discussionmentioning

confidence: 99%

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Tsai

Wong

Hsu

et al. 2022

Animals

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CORM-2 prevents human gingival fibroblasts from lipoteichoic acid-induced VCAM-1 and ICAM-1 expression by inhibiting TLR2/MyD88/TRAF6/PI3K/Akt/ROS/NF-κB signaling pathway

Cheng

Chen

et al. 2022

Biochemical Pharmacology

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Targeting Nrf2 with Probiotics and Postbiotics in the Treatment of Periodontitis

2022

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Periodontitis is a destructive disease of the tooth-surrounding tissues. Infection is the etiological cause of the disease, but its extent and severity depend on the immune–inflammatory response of the host. Immune cells use reactive oxygen species to suppress infections, and there is homeostasis between oxidative and antioxidant mechanisms during periodontal health. During periodontitis, however, increased oxidative stress triggers tissue damage, either directly by activating apoptosis and DNA damage or indirectly by activating proteolytic cascades. Periodontal treatment aims to maintain an infection and inflammation-free zone and, in some cases, regenerate lost tissues. Although mechanical disruption of the oral biofilm is an indispensable part of periodontal treatment, adjunctive measures, such as antibiotics or anti-inflammatory medications, are also frequently used, especially in patients with suppressed immune responses. Recent studies have shown that probiotics activate antioxidant mechanisms and can suppress extensive oxidative stress via their ability to activate nuclear factor erythroid 2-related factor 2 (Nrf2). The aim of this narrative review is to describe the essential role of Nrf2 in the maintenance of periodontal health and to propose possible mechanisms to restore the impaired Nrf2 response in periodontitis, with the aid of probiotic and postbiotics.

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Surfactin reduces particulate matter–induced VCAM‐1–dependent monocyte adhesion in human gingival fibroblasts by increasing Nrf2‐dependent HO‐1 expression

Cited by 3 publications

References 54 publications

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice

CORM-2 prevents human gingival fibroblasts from lipoteichoic acid-induced VCAM-1 and ICAM-1 expression by inhibiting TLR2/MyD88/TRAF6/PI3K/Akt/ROS/NF-κB signaling pathway

Targeting Nrf2 with Probiotics and Postbiotics in the Treatment of Periodontitis

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