Surfactant therapy improves pulmonary function in infants withPneumocystis carinii pneumonia and acquired immunodeficiency syndrome

Pulmonary Inflammation Disrupts Surfactant Function duringPneumocystis cariniiPneumonia

“…Consistent with our findings of surfactant abnormalities during PCP, other studies have found that surfactant replacement therapy can improve pulmonary function during PCP (6,7,22). In addition to restoring critical components, exogenous surfactant may also benefit PCP patients by inhibiting T-cell-dependent inflammatory responses (5) and diminishing neutrophil function (53).…”

The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections

“…One case report demonstrated oxygenation improvement with intrabronchial instillation of surfactant in an adult patient with gram-negative lobar pneumonia (119). Other case reports demonstrate similar oxygen improvements in HIV-infected infants with P. carinii pneumonia (120,121) or RSV pneumonia (122). One RCT of a 2-week treatment course with aerosolized synthetic surfactant showed improved pulmonary function in adult patients with stable chronic bronchitis (123).…”

Increased expression of apoptosis signalling receptors by alveolar macrophages in sarcoidosis

“…Selective intrabronchial instillation of surfactant via a flexible bronchoscope in an adult patient with lobar Gram-negative pneumonia resulted in a small improvement in oxygenation [175]. Similar improvements have been seen in HIV-infected infants with P. carinii pneumonia [176,177] or pneumonia caused by Respiratory syncytial virus [178].…”