Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock

Gibot, Sébastien; Renard, Pol-Edern Le; Bollaert, Pierre‐Édouard; Kolopp‐Sarda, Marie‐Nathalie; Béné, Marie‐Christine; Fauré, G; Lévy, Bruno

doi:10.1007/s00134-005-2572-x

Cited by 88 publications

(83 citation statements)

References 19 publications

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“…TREM-1 expression is increased during both acute ( 49,50 ) and chronic infl ammation ( 51 ). Moreover, a soluble form of TREM-1 was detected in the blood sample of human patients with infl ammatory disorders, such as sepsis ( 52 ), pneumonia ( 53 ), acute pancreatitis ( 54 ), and peptic ulcer disease ( 55 ). Very recently, Kuai et al reported that TREM-1 expression is increased in the synovium of RA patients ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines

Chang

Sardella

Chun

et al. 2011

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines

Chang

Sardella

Chun

et al. 2011

Journal of Lipid Research

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“…In contrast, the DAP12-associated receptor TREM-1 is up-regulated upon monocyte and neutrophil activation by fungus and extracellular bacteria, and especially by LPS and lipoteichoic acid which are microbial components, but not nonbacterial TLR ligands (7,10,23). TREM-1 is also up-regulated in neutrophils of patients with pneumonia (24) and in monocytes of patients suffering from septic shock (23,25) indicating a role in the detection and response to microbial infection. In contrast, hOSCAR expression did not change in the conditions of neutrophil activation analyzed in this study, suggesting that the physiologic regulation of hOSCAR reactivity during inflammatory responses may depend on availability or regulation of the expression of the counter-receptor.…”

Section: Discussionmentioning

confidence: 99%

Ligation of the FcRγ Chain-Associated Human Osteoclast-Associated Receptor Enhances the Proinflammatory Responses of Human Monocytes and Neutrophils

Merck¹,

Gaillard²,

Scuiller³

et al. 2006

The Journal of Immunology

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We have previously described the human osteoclast associated receptor (hOSCAR), expressed in all cells of the myeloid lineage, and its immune functions. This receptor, which associates with the FcRγ chain to transduce an activating signal, induces calcium flux in monocytes and dendritic cells, and modulates specific responses of dendritic cells. In this study, we have examined the effects of hOSCAR ligation on various proinflammatory responses of monocytes and neutrophils. Monocytes stimulated via hOSCAR ligation released IL-8/CXCL8 and other chemokines such as epithelial neutrophil-activating peptide-78/CXCL5, macrophage-derived chemokine/CCL22, and MCP-1/CCL2 and up-regulated markers involved in cell adhesion and costimulatory functions. Monocytes stimulated via hOSCAR in the absence of survival factors had an increased life span. Although the life span of neutrophils was unaffected, these cells, when stimulated via hOSCAR, rapidly released reactive oxygen intermediates, degranulated lactoferrin, myeloperoxidase, and matrix metalloproteinase-9 and also secreted IL-8/CXCL8. Neutrophils also underwent changes in cell surface molecule expression with the cleavage of CD62L and increased expression of CD11b and CD66b after 2-h stimulations. Finally, we demonstrated synergy between hOSCAR and TLR ligands on both monocytes and neutrophils, with up to 8-fold increases in cytokine secretion when hOSCAR was cross-linked in the presence of LPS or R-848. Overall, our data demonstrate that hOSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses.

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“…TREM-1 expression is up-regulated in myeloid cells after LPS stimulation (45) or during sepsis (49). TREM-2 expression is associated with regulating myeloid lineage development (50).…”

Section: Discussionmentioning

confidence: 99%

Head Kidney-Derived Macrophages of Common Carp (Cyprinus carpio L.) Show Plasticity and Functional Polarization upon Differential Stimulation

Joerink

Ribeiro

Stet

et al. 2006

The Journal of Immunology

135

109

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Cells from the myeloid lineage are pluripotent. To investigate the potential of myeloid cell polarization in a primitive vertebrate species, we phenotypically and functionally characterized myeloid cells of common carp (Cyprinus carpio L.) during culture. Flow cytometric analysis, Ab labeling of cell surface markers, and light microscopy showed the presence of a major population of heterogeneous macrophages after culture. These head kidney-derived macrophages can be considered the fish equivalent of bone marrow-derived macrophages and show the ability to phagocytose, produce radicals, and polarize into innate activated or alternatively activated macrophages. Macrophage polarization was based on differential activity of inducible NO synthase and arginase for innate and alternative activation, respectively. Correspondingly, gene expression profiling after stimulation with LPS or cAMP showed differential expression for most of the immune genes presently described for carp. The recently described novel Ig-like transcript 1 (NILT1) and the CXCR1 and CXCR2 chemokine receptors were up-regulated after stimulation with cAMP, an inducer of alternative activation in carp macrophages. Up-regulation of NILT1 was also seen during the later phase of a Trypanosoma carassii infection, where macrophages are primarily alternatively activated. However, NILT1 could not be up-regulated during a Trypanoplasma borreli infection, a model for innate activation. Our data suggest that NILT1, CXCR1, and CXCR2 could be considered markers for alternatively activated macrophages in fish.

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Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock

Abstract: The specificity of TREM-1 regulation by infection is highlighted. Moreover, surface TREM-1 expression on monocytes may prove useful in allowing the follow-up of septic patients during the course of the disease.

Cited by 88 publications

References 19 publications

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines

Ligation of the FcRγ Chain-Associated Human Osteoclast-Associated Receptor Enhances the Proinflammatory Responses of Human Monocytes and Neutrophils

Head Kidney-Derived Macrophages of Common Carp (Cyprinus carpio L.) Show Plasticity and Functional Polarization upon Differential Stimulation

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