2002
DOI: 10.1590/s1517-74912002000300005
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Surface topography of hydroxyapatite affects ROS17/2.8 cells response

Abstract: Hydroxyapatite (HA) has been used in orthopedic, dental, and maxillofacial surgery as a bone substitute. The aim of this investigation was to study the effect of surface topography produced by the presence of microporosity on cell response, evaluating: cell attachment, cell morphology, cell proliferation, total protein content, and alkaline phosphatase (ALP) activity. HA discs with different percentages of microporosity (< 5%, 15%, and 30%) were confected by means of the combination of uniaxial powder pressing… Show more

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Cited by 19 publications
(10 citation statements)
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“…37 Scaffolds impregnated with HAps increased in vitro bone nodule formation, as well as in vivo bone formation, 38 providing an appropriate osteogenic environment for tissue engineering. 39 The mineralization of silk fibroin scaffolds provides increased osteoconductive environment for BMSCs to construct tissue engineered bone to repair mandible defects in large animal. 810 In this work, we confirmed that AS can mediate the nucleation of HAps according to Figures 2–4.…”
Section: Resultsmentioning
confidence: 99%
“…37 Scaffolds impregnated with HAps increased in vitro bone nodule formation, as well as in vivo bone formation, 38 providing an appropriate osteogenic environment for tissue engineering. 39 The mineralization of silk fibroin scaffolds provides increased osteoconductive environment for BMSCs to construct tissue engineered bone to repair mandible defects in large animal. 810 In this work, we confirmed that AS can mediate the nucleation of HAps according to Figures 2–4.…”
Section: Resultsmentioning
confidence: 99%
“…They also play a significant role on the long-term success of implants and their interaction with the surrounding tissue [29], as modifications on chemical and physical properties of implants can influence cell behavior [8,11,12,15,16,22,27,[30][31][32][33]. Materials for biomedical implants should present excellent biological properties and suitable mechanical properties [33].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…In addition, compared with the scaffolds obtained using PVP, the viability of cells cultured on the scaffolds obtained using gelatin was higher. It has been reported that surface roughness, topography in microscale [45][46][47] and nanoscale 48,49 can influence cell morphology and proliferation. The adhesion and spreading of cells on porous scaffolds have been examined by SEM.…”
Section: Porosity and Compressive Strengthmentioning
confidence: 99%