Surface Modification of Citrate-Reduced Colloidal Gold Nanoparticles with 2-Mercaptosuccinic Acid

Abstract

Surface modification of citrate-reduced gold nanoparticles with 2-mercaptosuccinic acid (MSA) was carried out in the aqueous phase. This provides a way to obtain carboxylic acid functionalized gold nanoparticles with diameter above 10 nm. The influence of the protecting MSA layer on the behavior of the modified gold nanoparticles in comparison with that of the traditional citrate-reduced gold colloid was evaluated by HCl titration, cyanide etching, and seeded growth tests. The modified gold nanoparticles show an improved stability against pH changes and cyanide etching. They do show further growth, which appears to be more homogeneous than for the unmodified particles.

Toward Greener Nanosynthesis

“…253 For many years, the most successful ligand exchange methods employed a thiol bearing an anionic ω-functionality. [254][255][256] One example of this type of exchange, involving thioctic acid as a ligand, is shown in Figure 30.…”

Preparation of Magnetic Microsphere‐Gold Nanoparticle‐Immobilized Enzyme Batch Reactor and Its Application to Enzyme Inhibitor Screening in Natural Extracts by Capillary Electrophoresis

“…[7] It has been verified that the enzymes immobilized on magnetic nanoparticles can be easily separated from the reaction medium, stored, and reused with consistent results. [8] Although magnetic microspheres (MB) have been already prepared and used for the immobilization of various enzymes, [9][10][11] a few investigations were only deal with the screening of enzyme inhibitors from natural products by CE. The gold nanoparticles (AuNPs) possess a vast surface-tomass ratio, which can enrich enzyme on its surface, and then assembled onto the MB to form an AuNPs-mediated enzyme bioreactor.…”

Rapid Cationization of Gold Nanoparticles by Two‐Step Phase Transfer

“…For these reasons, citrate-AuNPs have been functionalized with stabilizing ligands including various amines [28] and thiols such as thiolated DNA, [29] polymers containing thiol or disulfide groups [30,31] and small thiol molecules, e.g. mercaptosuccinic acid, [32] cysteine, [33] thioctic acid, [34] or hydrophobic thiols. [35] However, most of these systems produce negatively charged AuNPs because direct functionalization with a positively charged ligand typically leads to unwanted aggregation of AuNPs due to the detrimental electrostatic attraction between the ligands ( Figure S1).…”