Surface Microscopy of Pigmented Basal Cell Carcinoma

Menzies, Scott W.; Westerhoff, Karin; Rabinovitz, Harold; Kopf, Alfred W.; McCarthy, William H.; Katz, Brian

doi:10.1001/archderm.136.8.1012

Cited by 326 publications

(423 citation statements)

References 20 publications

(27 reference statements)

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“…here have been several recent reports of the apparently successful use of topical tacrolimus in the treatment of genital lichen sclerosus (LSc), [1][2][3][4] 2 of which have appeared in the Archives of Dermatology. 1,2 Genital squamous cell carcinoma is an established risk in the context of a chronic inflammatory scarring dermatosis such as LSc.…”

mentioning

confidence: 99%

“…1,2 Genital squamous cell carcinoma is an established risk in the context of a chronic inflammatory scarring dermatosis such as LSc. 5,6 All too frequently in situ and invasive carcinoma is unsuspected, misdiagnosed, or diagnosed late, with dire consequences.…”

mentioning

confidence: 99%

“…In our case, the blue-gray structures were similar to the so-called blue-gray ovoid nests, which are a dermoscopic hallmark of pigmented basal cell carcinoma. 2,3 The clinical features and the additional dermoscopic observation of comedolike open- ings, few milialike cysts, and the jelly sign were all in favor of the diagnosis of seborrheic keratosis. 3,4 However, the presence of blue-gray ovoid nests raised the need for a histopathologic examination, which revealed a clonal seborrheic keratosis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clonal Seborrheic Keratosis: A Dermoscopic Pitfall

Zalaudek¹,

Ferrara²,

Argenziano³

2004

Arch Dermatol

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confidence: 99%

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confidence: 99%

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confidence: 99%

See 1 more Smart Citation

Clonal Seborrheic Keratosis: A Dermoscopic Pitfall

Zalaudek¹,

Ferrara²,

Argenziano³

2004

Arch Dermatol

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“…29 ( Figure 8) Pigmentation in basal cell carcinoma is primarily related to presence of melanin in the tumor mass (hyperplastic melanocytes or melanosomas phagocyted by the tumor) and is important in differential diagnosis with cutaneous melanoma, particularly if much pigmented.…”

Section: Pigmented Basal Cell Carcinomamentioning

confidence: 99%

Dermatoscopia: o método de análise de padrões

Rezze

Sá

Neves

2006

An. Bras. Dermatol.

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Abstract:The incidence of cutaneous melanoma is increasing worldwide. Since it has an aggressive behavior and difficult to treat in more advanced stages, early diagnosis is essential for cure. Dermoscopy is an auxiliary diagnostic method that allows an increase in the diagnostic accuracy for cutaneous melanoma using a hand-held microscope with a 10-fold magnification -a dermatoscope. The pattern analysis method is considered a reliable procedure to teach dermatology residents. It is based on global and specific patterns that enable classifying melanocytic and non-melanocytic lesions (which are important in the differential diagnosis of cutaneous melanoma INTRODUCTIONThe incidence of melanoma has doubled all over the world in fair-skin patients over the past 10 years.1 The highest incidence and mortality rates in the world are recorded in Australia, where it is the most common type of cancer in men and it ranks second in women, in the age group 15-44 years; therefore, it is considered a public health problem.

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“…For instance, a two-step method was proposed in [20]; the first step is differentiate between melanocytic and non-melanocytic lesions, and in the second step four different algorithms are applied to differentiate melanoma from other benign melanocytic lesions [20]. Furthermore, Menzies et al used dermoscopy to examine pigmented basal cell carcinomas and they established a diagnostic technique that for a lesion to be diagnosed as pigmented basal cell carcinoma it should have one or more of these 6 features: large gray-blue ovoid nests, multiple gray-blue globules, maple leaf-like areas, spoke wheel areas, ulceration, and arborizing tree-like telangiectasia [27]. In that research, based on independent test sets, sensitivity of 97% was measured for the diagnosis of pigmented basal cell carcinoma and specificity of 93% and 92% were measured for the diagnosis of invasive melanomas and benign pigmented skin lesions [27].…”

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confidence: 99%

Skin cancer detection using laser imaging

Mowla¹

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Endeavors to develop a non-invasive and reliable device to detect different types of skin cancer in its early stages have been undertaken over the past few years. Although some advances have been made towards such developments, there remains great scope for the development of a non-expensive, compact, reliable, safe, easy to use, fast, sensitive, and non-invasive device. This project will apply the innovative laser feedback interferometry (LFI) technique to skin cancer detection via laser imaging using near-infrared vertical cavity surface emitting lasers (VCSELs). In this project, the science behind lighttissue interactions has been explored and skin imaging modalities have been elaborately studied. As a result, LFI has been exploited in various configurations to image different modalities such as Doppler flowmetry and confocal reflectance. In addition to single modality imaging, dual-modality imaging has also been proposed and conducted experimentally, to image Doppler flowmetry and confocal reflectance at the same time, using an integrated LFI system. It is shown that dual-modality imaging can yield images with higher contrast which provide more information about morphological and functional characteristics of a target under test.In addition to two-dimensional LFI imaging, three-dimensional imaging systems have also been studied and employed in the laboratory. A tomographic image identifies tissue volume with altered optical properties due to cancerous or other malignant tissue processes. We applied the three-dimensional imaging system to different types of keratinocyte skin cancer phantoms and results show high level of sensitivity in providing tomographic images. Using high numerical aperture lenses, making images at resolutions down to micrometer scales is possible, which is promising for microscopy of biological structures.Furthermore, parallel LFI imaging using an array of 24 VCSELs was also studied theoretically and experimentally as a part of this work. A VCSEL array was used in a parallel read-out LFI imaging system to develop a fast and high resolution device, which eliminates the need to scan mechanically in one dimension.Investigating the complex interactions of the laser beam and tissue requires a powerful and robust simulation technique. Monte Carlo was used as a simulation technique to model the light-tissue interactions occurring in the optical systems in this work. Firstly, we tested and validated the Monte Carlo main engine which was developed in the group, by studying morphological aspects of the simulated and experimental signals in a laser Doppler velocimetry system, and deep insight into the nature of the LFI Doppler spectrum and further conclusions were drawn. Secondly, the Monte Carlo engine was used in iii modeling and analyzing of optical systems, in this work.We developed tissue phantom making techniques which were used to examine the experimental ideas in place of biological samples which are difficult to obtain and work with. Therefore, tissue phantom techniques were studie...

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Surface Microscopy of Pigmented Basal Cell Carcinoma

Cited by 326 publications

References 20 publications

Clonal Seborrheic Keratosis: A Dermoscopic Pitfall

Clonal Seborrheic Keratosis: A Dermoscopic Pitfall

Dermatoscopia: o método de análise de padrões

Skin cancer detection using laser imaging

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