Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats

Tengvall, Pentti; Skoglund, Björn; Askendal, Agneta; Aspenberg, Per

doi:10.1016/j.biomaterials.2003.08.049

Cited by 141 publications

(155 citation statements)

References 30 publications

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“…The SMI of 0.6 that characterized the bone in the bonehealing zone of the ZoleGel-group at day 58 compared to an SMI of 2.6 in the Control-group confirmed that the very compact woven bone had not yet remodeled. Findings in similar studies provide enough evidence to show that Zoledronate treated bone can enhance implant fixation despite the reduced mechanical competence of the immature bone structure [18,19,22]. Furthermore, Amanat et al showed with an indentation study that Zoledronate has no influence on the intrinsic mechanical properties of healing bone [60].…”

Section: Discussionmentioning

confidence: 93%

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Kettenberger

Ston

Thein³

et al. 2014

Biomaterials

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a b s t r a c tBisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilaterally in predrilled holes before inserting polymer screws. Static and dynamic bone parameters were analyzed based on in vivo microCT scans performed first weekly and then biweekly. The results showed that the locally released Zoledronate boosted bone formation rate up to 100% during the first 17 days after implantation and reduced the bone resorption rate up to 1000% later on. This shift in bone remodeling resulted in an increase in bone volume fraction (BV/TV) by 300% close to the screw and 100% further away. The double effect on bone formation and resorption indicates a great potential of Zoledronateloaded hydrogel for enhancement of peri-implant bone volume which is directly linked to improved implant fixation.

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Section: Discussionmentioning

confidence: 93%

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Kettenberger

Ston

Thein³

et al. 2014

Biomaterials

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“…Tengvall et al [39] showed an increase by 28% of the pullout force of steel screws inserted in rat femurs by using a fibrinogen/pamidronate/ibandronate coating. In the present study, the implants containing 2.1 Ag of zoledronate induced an increase in pullout force up to 42% compared to implants without zoledronate.…”

Section: Discussionmentioning

confidence: 99%

“…This study showed a 10% increase in bone contact area. Tengvall et al [39] showed a 28% increase in pullout force and 90% pullout energy when comparing stainless steel screws with the same type of screws but coated with a fibrinogen coating containing pamidronate and implanted in rat tibia. In the limit of our knowledge, no information can be found about the optimal bisphosphonate quantity needed to achieve an increase specifically in fixation of orthopedic implant.…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Peter

Pioletti

Laı̈b

et al. 2005

Bone

252

167

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Despite total hip replacement (THR) gives generally satisfactory results, the quality of outcome in young patients is markedly decreased compared to the average THR outcome. For this population, pharmacological treatment with bisphosphonate would be beneficial to decrease the peri-implant osteolysis. However, as this population does not necessarily suffer from osteoporosis, a nonsystemic treatment would be preferable. Zoledronate was then grafted to hydroxyapatite (HA) coating of titanium implants. The implants were inserted in rat condyles with various zoledronate concentrations. A positive concentration-dependent effect was observed on the peri-implant bone density and on different histomorphometric parameters. Importantly for the outcome of the implants, the mechanical fixation was increased by the local presence of zoledronate.The obtained results open the way of an easy transformation of currently existing HA-coated implants by grafting bisphosphonate onto the coating in order to increase their service life in the patients. D 2004 Elsevier Inc. All rights reserved.

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“…This type of screw has been used in several previous studies on implant fixation , Tengvall et al 2004. The heads of the screws were designed with a hole, so that they could be fastened to a hook in a materials testing machine.…”

Section: Preparation Of Stainless-steel Screwsmentioning

confidence: 99%

“…We have shown previously that stainless steel screws with a bisphosphonate coating improve the mechanical fixation of implants in rat tibia, as measured at 2 weeks (Tengvall et al 2004). In principle, bisphosphonates could exert this effect in two different ways: The first way would be by blocking the early bone resorption that is initiated by the tissue damage at surgery (Dhert et al 1998).…”

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confidence: 99%

Surface-bound bisphosphonates enhance screw fixation in rats—increasing effect up to 8 weeks after insertion

2007

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Background A bisphosphonate coating improves screw fixation 2 weeks after implantation in cancellous bone. This study on rats examined further development of fixation over time for screws inserted in cancellous and cortical bone.Methods SS screws were coated with a multiple layer of fibrinogen. Half of the screws were coated further with bisphosphonates, which were linked to the fibrinogen. The screws were inserted in cancellous and cortical bone in rats. The rats were killed after 5 h, 4 days, 1, 2, 4, 8, and 24 weeks, and fixation was evaluated by pullout test.Results There was a gradual increase in pull-out force over time in both cancellous and cortical bone. The bisphosphonate coating improved fixation. Moreover, the difference between the bisphosphonate and control groups increased with time. The pull-out force was almost twice that of the controls for screws inserted in cancellous bone at 8 weeks. Energy uptake was increased more than 3-fold. Discussion The energy uptake and pull-out force of a screw depends on the bone engaged with the threads. Thus, the presence of bisphosphonates increased the amount or quality of this bone by affecting the resorption/formation in a positive way. The increased effect of the bisphosphonates with time thus suggests that bisphosphonate is retained within the remodeling bone, with a positive effect on its gradual adaptation to the implant.

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Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats

Cited by 141 publications

References 30 publications

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

Surface-bound bisphosphonates enhance screw fixation in rats—increasing effect up to 8 weeks after insertion

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