Surface functionalized folate targeted oleuropein nano-liposomes for prostate tumor targeting: In vitro and in vivo activity

Nassir, Anmar; Ibrahim, Ibrahim A.; Shadab,; Waris,; Tanuja,; Ain, Mohammad Ruhal; Ahmad, Iqbal; Shahzad, Naiyer

doi:10.1016/j.lfs.2019.01.053

Cited by 35 publications

(29 citation statements)

References 30 publications

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“…70,71 It is possible that treatment with OL or Per-OL maintained for long periods could have cumulative effects in specific anatomical sites. Further studies on this topic and on novel administration routes, 72 and on protection strategies to avoid intense exposure to metabolic detoxification pathways 73,74 of OL and Per-OL are needed to substantiate our findings. This will pave the way for novel strategies to protect bone health, opening up new directions in research against the development and progression of osteoclast-related diseases.…”

Section: Food and Function Papermentioning

confidence: 78%

Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

et al. 2020

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Section: Food and Function Papermentioning

confidence: 78%

Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

et al. 2020

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“…Similar antitumor benefits were observed by using NE loaded with catwechin extract (flavanols with anticancer properties) in PC-3 cells [122]. With respect to liposomes, 22Rv1 PrC cells were exposed to PEG-folate-targeted-oleuropein-liposomes [123]. These nanoplatforms increased the level of 22Rv1 cell apoptosis, the oleuropein bioavailability and the survival in in vivo models [123].…”

Section: Application Of Lipid-based Nanoparticles In Cancer Therapymentioning

confidence: 87%

“…With respect to liposomes, 22Rv1 PrC cells were exposed to PEG-folate-targeted-oleuropein-liposomes [123]. These nanoplatforms increased the level of 22Rv1 cell apoptosis, the oleuropein bioavailability and the survival in in vivo models [123]. In addition, NPs were developed by Hua et al [124] that consisted of a multifunctional liposome loaded with docetaxel and gold nanorod, showing 100% inhibition of PrC cell growth by combining the system with the application of a laser.…”

Section: Application Of Lipid-based Nanoparticles In Cancer Therapymentioning

confidence: 99%

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

et al. 2019

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Many therapeutically active molecules are non-soluble in aqueous systems, chemically and biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. LBNPs advantages include high temporal and thermal stability, high loading capacity, ease of preparation, low production costs, and large-scale industrial production since they can be prepared from natural sources. Moreover, the association of chemotherapeutic agents with lipid nanoparticles reduces active therapeutic dose and toxicity, decreases drug resistance and increases drug levels in tumor tissue by decreasing them in healthy tissue. LBNPs have been extensively assayed in in vitro cancer therapy but also in vivo, with promising results in some clinical trials. This review summarizes the types of LBNPs that have been developed in recent years and the main results when applied in cancer treatment, including essential assays in patients.

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“…The affinity of gold nanoparticles for biomolecules makes them appropriate options for gene and drug delivery [ 238 ]. As an example, the folate receptor is upregulated in PCa cells, and surface modification of nanocarriers with folic acid was shown to enhance the capability of nanoparticles in targeting PCa cells [ 239 ]. siRNA-RelA-loaded gold nanoparticles were able to diminish the survival of PCa cells via selective targeting of folate receptors, with diminishment of proliferation and survival of cancer cells resulting from the improved gene silencing (up to 35%) in comparison to control and free siRNA [ 240 ].…”

Section: Nano-vehiclesmentioning

confidence: 99%

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

et al. 2020

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Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early stages. Recently, the research focus was directed toward gene editing in cancer therapy. Small interfering RNA (siRNA) intervention is considered as a powerful tool for gene silencing (knockdown), enabling the suppression of oncogene factors in cancer. This strategy is applied to the treatment of various cancers including PCa. The siRNA can inhibit proliferation and invasion of PCa cells and is able to promote the anti-tumor activity of chemotherapeutic agents. However, the off-target effects of siRNA therapy remarkably reduce its efficacy in PCa therapy. To date, various carriers were designed to improve the delivery of siRNA and, among them, nanoparticles are of importance. Nanoparticles enable the targeted delivery of siRNAs and enhance their potential in the downregulation of target genes of interest. Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The efficacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa therapy and perhaps other cancer types.

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Surface functionalized folate targeted oleuropein nano-liposomes for prostate tumor targeting: In vitro and in vivo activity

Cited by 35 publications

References 30 publications

Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

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