Surface Epithelial Tumors of the Ovary

Seidman, Jeffrey D.; Cho, Kathleen R.; Ronnett, Brigitte M.; Kurman, Robert J.

doi:10.1007/978-1-4419-0489-8_14

Cited by 116 publications

(168 citation statements)

References 362 publications

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“…The tumours were classified into benign, borderline and malignant categories based on the WHO classification [4]. Immunohistochemistry was done in cases of mucinous cystadenocarcinoma to prove that they were primary ovarian carcinoma and to exclude metastatic tumours [5,6].…”

Section: Methodsmentioning

confidence: 99%

“…These tumours assume a wide array of histological pattern making it an interesting topic for study. Knowledge of the type of tumour and differentiation helps in judicious management of the patient in terms of appropriate treatment and follow-up [4][5][6]. The aim of this study was to categorise these lesions into benign, borderline and malignant, to study their clinical and histopathological pattern and to compare their incidences with other studies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological Study of Surface Epithelial Tumours of the Ovary: An Institutional Study

Modepalli

Venugopal

2016

JCDR

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathological Study of Surface Epithelial Tumours of the Ovary: An Institutional Study

Modepalli

Venugopal

2016

JCDR

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“…The histologic diagnoses were verified by concurrent pathologic review by two co-authors (NA and WZ) using a variation on published criteria. 17 The second group consisted of 98 ovaries and fallopian tubes from 50 patients who had previously undergone a total hysterectomy and bilateral salpingo-oophorectomy for uterine diseases or for adnexal pathologic changes that were ultimately deemed to be non-neoplastic. Patients' age in the second group was matched to the first group.…”

Section: Case Selectionmentioning

confidence: 99%

Tubal origin of ‘ovarian’ low-grade serous carcinoma

et al. 2011

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Ovarian low-grade serous carcinomas are thought to evolve in a stepwise fashion from ovarian epithelial inclusions, cystadenomas, and borderline tumors. The current study was designed to gain insight into the origins of low-grade serous carcinomas (tubal versus ovarian) by comparatively evaluating the morphologic (secretory and ciliated cell distribution) and immunophenotypic (using antibodies to PAX8, tubulin, calretinin, and Ki67) attributes of its putative precursor lesions, the normal tubal epithelium, and the overt malignancy. A total of 226 adnexal tissues from 178 patients were studied, including 98 adnexae removed for non-neoplastic indications, 48 serous cystadenomas, 42 serous borderline tumors, and 38 low-grade serous carcinomas. Normal distal tubal epithelium comprised an admixture of PAX8 þ /tubulinÀ secretory cells and PAX8À/ tubulin þ ciliated cells with a proliferative index of B3%. The vast majority of ovarian surface epithelia displayed a mesothelial phenotype (calretinin þ /PAX8À/tubulinÀ) and low proliferative index (0% (12 per 1000)), although 4% of cases also displayed foci with tubal phenotype (calretininÀ/PAX8 þ /tubulin þ ). In contrast, most (78%) of the ovarian epithelial inclusions displayed a tubal phenotype and had a significantly higher proliferative index (1%) than ovarian surface epithelium, indicating that in most cases, the ovarian surface epithelium and ovarian epithelial inclusions are of different lineages. There was a progressive decrease in the population of ciliated cells, as evidenced by increasing secretory/ciliated cell ratio, from ovarian epithelial inclusions/cystadenomas to borderline tumors to low-grade serous carcinoma, indicating that the latter is a clonal expansion of secretory cells. Overall, the findings make a strong argument that the ovarian epithelial inclusions with a tubal phenotype is likely derived from fallopian tube through an intraovarian endosalpingiosis rather than through Mullerian metaplasia from ovarian surface epithelium. Genetic and molecular studies are needed to further confirm this finding as tubal origination of ovarian serous cancers will have a significant impact on ovarian cancer prevention and management.

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“…The mean age of the patients in our study was 65 years. Other authors have reported mean ages of 46.5 to 63 years [3,5]. Age also correlates with the disease type: benign Brenner tumors are usually found in patients aged between 35 and 65 years [6], while malignant and borderline tumors tend to occur in older patients [7].…”

Section: Discussionmentioning

confidence: 99%

“…These tumors are usually benign, with malignant change found only in around 5% of patients [2]. Brenner tumors are usually solid, unless they are associated with other cystic ovarian tumors [3]. Microscopically, such tumors consist of numerous islets of transitional or squamous epithelium, with some small tubules lined with cylindrical cells surrounded by fibrous tissue.…”

Section: Introductionmentioning

confidence: 99%