2015
DOI: 10.1126/scitranslmed.3010633
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Abstract: The inability to visualize the true extent of cancers represents a significant challenge in many areas of oncology. The margins of most cancer types are not well demarcated because the cancer diffusely infiltrates the surrounding tissues. Furthermore, cancers may be multifocal and characterized by the presence of microscopic satellite lesions. Such microscopic foci represent a major reason for persistence of cancer, local recurrences, and metastatic spread and are usually impossible to visualize with currently… Show more

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Cited by 240 publications
(272 citation statements)
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“…12 Owing to their biocompatibility, feasible surface modification and tiny size, gold nanoparticles (GNPs) have been used for drug delivery, tumor targeting, gene therapy and photothermal therapy. [5][6][7][8][9][10][11] However, Raman signals are inherently weak for in vivo imaging and drug location tracking. GNPs can provide broad wavelength for Raman scattering.…”
mentioning
confidence: 99%
“…12 Owing to their biocompatibility, feasible surface modification and tiny size, gold nanoparticles (GNPs) have been used for drug delivery, tumor targeting, gene therapy and photothermal therapy. [5][6][7][8][9][10][11] However, Raman signals are inherently weak for in vivo imaging and drug location tracking. GNPs can provide broad wavelength for Raman scattering.…”
mentioning
confidence: 99%
“…High sensitivity and broad applicability, in conjunction with their ine rt gold-silica composition, render SERRS nanostars a promising imaging agent for more precise cancer imaging and resection. (39) The plasmonic heating response of nanostar serves as a signature of nanoparticle internalization in cells, bringing the ultimate goal of nanoparticle-mediated photothermal therapy a step closer. Gold nanostars can be used for simultan eous photoacoustic imaging and photothermal therapy in living cancer cell.…”
Section: Nanostars:-mentioning
confidence: 99%
“…[1][2][3][4][5][6] The SERS substrate can also be designed to serve as a sensitive Raman probe for bioimaging under in vitro and in vivo environments. [7][8][9][10][11] Despite the remarkable progress in SERS, there are many bottlenecks hindering its development. The selection of metal, size, shape, and spacing of metal nanostructure have largely influenced the SERS effect.…”
Section: Introductionmentioning
confidence: 99%