Surface-enhanced Raman scattering aptasensor for ultrasensitive trace analysis of bisphenol A

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

“…Chung et al utilized this "SERS-off" molecularly mediated SERS methodology and used a partial complimentary sequence to immobilize an ssDNA aptamer onto Au/Ag core-shell nanoparticles. This method proved to be sensitive down to the 10-fm range for BPA-spiked tap water, over a total dynamic range of 10 fm-100 nm [160]. The authors of this work acknowledge that this LOD is two or three orders of magnitude lower than that reported for other BPA sensing techniques but may possibly be higher if the samples were in complex biological media.…”

Aptamer-functionalized nanoporous gold film for high-performance direct electrochemical detection of bisphenol A in human serum

“…These chromatography and mass spectrometry-based techniques can analyze BPA with high sensitivity, however, large capital investment, skilled operators, and cumbersome sample preparation and pretreatment are required, reducing their applicability of on-site and rapid detection of BPA in various samples and matrices [9,11]. The other recently developed methods for BPA detection include enzyme-linked immunosorbent assay (ELISA) [12], fluorescent method [13], surface-enhanced Raman scattering [14,15], colorimetric methods [16], and electrochemical sensors [17][18][19][20][21][22][23][24][25][26][27][28][29]. Among those methods, electrochemical sensors are the widely accepted and employed group due to their simple operation, rapid response time, low cost, high sensitivity, potential for miniaturization, and capability of real sample analysis [9], thereby having promising potential for BPA analysis in human internal fluids.…”

A novel electrochemiluminescence sensor based on Ru(bpy)32+/N-Li1, Yu2, Zhang3 et al. 2015Analytica Chimica Acta560160View full textAdd to dashboardCite

“…Various analytical methods including high performance liquid chromatography (HPLC) [3], gas chromatography (GC) [4], capillary electrophoresis (CE) [5], fluorescence (FL) [6], chemiluminescence (CL) [7], colorimetry [8] and surface-enhanced Raman scattering (SERS) [9] have been widely applied to quantify BPA. However, these developed methods are often related to complicated sample pretreatment, time-consuming process or poor detection limits.…”