Surface conditioning with cold argon plasma and its effect on the osseointegration of dental implants in miniature pigs

Naujokat, Hendrik; Harder, Sönke; Schulz, Lara Yasemin; Wiltfang, Jens; Flörke, Christian; Açil, Yahya

doi:10.1016/j.jcms.2018.12.011

Cited by 29 publications

(27 citation statements)

References 26 publications

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“…Because of its decontaminating properties, argon plasma (Ar), which is widely used as a coagulant in digestive surgery [ 73 ], has been proposed by certain authors [ 52 , 74 , 75 , 76 , 77 ] to improve early integration of Ti implants due to its decontaminating properties.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were “dental implants”, “bioactive surfaces”, “biofunctionalized surfaces”, and “osseointegration”, according to the question: “Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?” Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)—in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)—in 4 studies; shear force (SF)—in 1 study; bone-to-implant contact (BIC)—in 12 studies; and BIC and bone area (BA) jointly—in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of p < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium–phosphate (Ca–Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.

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Section: Discussionmentioning

confidence: 99%

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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“…Approaches to decontaminate the surfaces of dental implants have been developed, such as UV-mediated photofunctionalization and treatment with cold plasma or non-thermal plasma (González-Blanco et al, 2019). A previous study has shown that cold argon plasma promoted higher BIC values and bone density in a pig model (Naujokat et al, 2019). However, different from cold plasma, photofunctionalization has been studied extensively in animal models.…”

Section: Discussionmentioning

confidence: 99%

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Dini

Nagay

Magno

et al. 2020

Clinical Oral Implants Res

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Objectives To determine whether photofunctionalization influences dental implant osseointegration. Material and methods Data on osseointegration rates were extracted from 8 databases, based on bone‐to‐implant contact (BIC) and pushout tests. Internal validity was accessed through the SYRCLE risk of bias tool for animal experimental studies. Meta‐analyses were performed for investigation of the influence of photofunctionalization on implant osseointegration, with a random effect and a confidence interval of 95%. The certainty of evidence was accessed through the GRADE approach. Results Thirty‐four records were identified, and 10 were included in the meta‐analysis. Photofunctionalized implants showed higher mean values for BIC in rabbits (MD 6.92 [1.01, 12.82], p = .02), dogs (MD 23.70 [10.23, 37.16], p = .001), rats (MD 20.93 [12.91, 28.95], p < .0001), and in the pooled BIC analyses (MD 14.23 [7.80, 20.66], p < .0001) compared to those in control implants in the overall assay. Conversely, at late healing periods, the pooled BIC meta‐analyses showed no statistically significant differences (p > .05) for photofunctionalized and control implants at 12 weeks of follow‐up. For pushout analysis, photofunctionalized implants presented greater bone strength integration (MD 19.92 [13.88, 25.96], p < .0001) compared to that of control implants. The heterogeneity between studies ranged from “not important” to “moderate” for rabbits I2 = 24%, dogs I2 = 0%, rats I2 = 0%, and pooled BIC (I2 = 49%), while considerable heterogeneity was observed for pushouts (I2 = 90%). Conclusion Photofunctionalization improves osseointegration in the initial healing period of implants, as summarized from available data from rabbit, dog, and rat in vivo models.

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“…However, groups treated with LTP exhibited increased bone-to-implant contact ratio, inter-thread, and peri-implant bone density compared to the controls. Interestingly, newly formed bone presented chronological and consistent mineralization, and no undesirable peri-implant side effects were present [82].…”

Section: Ltp To Optimize Implant Surfacesmentioning

confidence: 97%

“…Argon-based plasma jet (kINPen [82] biofilms treated with LTP showed substantial CFU decrease, change in morphology, and decreased viability when compared to control treatments. Additionally, fluorescence microscopy revealed the occurrence of ROS in all biofilms treated with LTP.…”

Section: Surface Modification and Osseointegrationmentioning

confidence: 99%

Comprehensive biomedical applications of low temperature plasmas

Duarte

Panariello

2020

Archives of Biochemistry and Biophysics

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The main component of plasma medicine is the use of low-temperature plasma (LTP) as a powerful tool for biomedical applications. LTP generates high reactivity at low temperatures and can be activated with noble gases with molecular mixtures or compressed air. LTP reactive species are quickly produced, and are a remarkably good source of reactive oxygen and nitrogen species including singlet oxygen (O 2), ozone (O 3), hydroxyl radicals (OH), nitrous oxide (NO), and nitrogen dioxide (NO 2). Its low gas temperature and highly reactive nonequilibrium chemistry make it appropriate for the alteration of inorganic surfaces and delicate biological systems. Treatment of oral biofilm-related infections, treatment of wounds and skin diseases, assistance in cancer treatment, treatment of viruses' infections (e.g. herpes simplex), and optimization of implants surfaces are included among the extensive plasma medicine applications. Each of these applications will be discussed in this review article.

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Surface conditioning with cold argon plasma and its effect on the osseointegration of dental implants in miniature pigs

Cited by 29 publications

References 26 publications

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Comprehensive biomedical applications of low temperature plasmas

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