Surface charge control for zwitterionic polymer brushes: Tailoring surface properties to antifouling applications

Guo, Shan; Jańczewski, Dominik; Zhu, Xiaoying; Quintana, Robert; He, Tao; Neoh, K. G.

doi:10.1016/j.jcis.2015.04.013

Cited by 133 publications

(112 citation statements)

References 62 publications

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“…Thus, the experimentally attainable ζ potential is a highly useful parameter to characterize the surface charge. It is generally observed that a positive surface ζ potential promotes bacterial cell adhesion while neutral or negative surface ζ potential is able to resist cell adhesion [27,43]. Similar phenomena have also been observed for mammalian cell lines [44].…”

Section: Surface Chargesupporting

confidence: 61%

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Guo

Zhu

Loh

2017

Materials Science and Engineering: C

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Section: Surface Chargesupporting

confidence: 61%

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Guo

Zhu

Loh

2017

Materials Science and Engineering: C

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“…This critical number seems to depend on the global charge density of the polymer itself (functional groups per nm 2 ), the distance up to which these groups can be approached (i.e., whether direct surface access is blocked by PEG or polyzwitterion chains), and the electrostatic charge of the bacteria themselves. For example, it is known that E. coli bacteria approximately have a 5 times greater surface area per cell and an up to 15 times larger negative surface potential than S. aureus [42,43]. Thus, E. coli bacteria have more negative charges per cell available for electrostatic binding to the SMAMP moieties.…”

Section: Resultsmentioning

confidence: 99%

Surface-Attached Poly(oxanorbornene) Hydrogels with Antimicrobial and Protein-Repellent Moieties: The Quest for Simultaneous Dual Activity

Kurowska¹,

Widyaya²,

Al‐Ahmad³

et al. 2018

Materials

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By copolymerizing an amphiphilic oxanorbornene monomer bearing N- tert-butyloxycarbonyl (Boc) protected cationic groups with an oxanorbornene-functionalized poly(ethylene glycol) (PEG) macromonomer, bifunctional comb copolymers were obtained. Varying the comonomer ratios led to copolymers with PEG contents between 5–25 mol %. These polymers were simultaneously surface-immobilized on benzophenone-bearing substrates and cross-linked with pentaerythritoltetrakis(3-mercaptopropionate). They were then immersed into HCl to remove the Boc groups. The thus obtained surface-attached polymer hydrogels (called SMAMP*-co-PEG) were simultaneously antimicrobial and protein-repellent. Physical characterization data showed that the substrates used were homogeneously covered with the SMAMP*-co-PEG polymer, and that the PEG moieties tended to segregate to the polymer–air interface. Thus, with increasing PEG content, the interface became increasingly hydrophilic and protein-repellent, as demonstrated by a protein adhesion assay. With 25 mol % PEG, near-quantitative protein-adhesion was observed. The antimicrobial activity of the SMAMP*-co-PEG polymers originates from the electrostatic interaction of the cationic groups with the negatively charged cell envelope of the bacteria. However, the SMAMP*-co-PEG surfaces were only fully active against E. coli, while their activity against S. aureus was already compromised by as little as 5 mol % (18.8 mass %) PEG. The long PEG chains seem to prevent the close interaction of bacteria with the surface, and also might reduce the surface charge density.

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“…[27][28][29][30] Sulfobetaine pendant groups have strong hydration capacity due to the ionic solvation. [31][32][33][34] The use of surface-initiated atom transfer radical polymerization (SI-ATRP) for the preparation of polymer brushes enables precise control of their architectural features, such as the grafting density, the thickness and the composition; therefore, the interfacial properties of polymer films can be tuned flexibly. 35,36 It is important to explore the structure-property relationship of sulfobetaine-based polymer brushes for better understanding of their correlation with the formation of fog and frost on these surfaces.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic polymer brush coatings with excellent anti-fog and anti-frost properties

Ezzat

Huang

2016

RSC Adv.

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The formation of fog and frost on transparent surfaces can lead to many problems in our daily life. To address these problems, polymer brushes based on two zwitterionic analogues, poly(sulfobetaine methacrylate) (pSBMA) and poly(sulfobetaine vinylimidazole) (pSBVI), have been prepared by surface-initiated atom transfer radical polymerization (SI-ATRP). Hydrophilic and superhydrophilic pSBMA and pSBVI polymer brushes were prepared by controlling the thickness of the coatings to study the effect of wettability on the anti-fog and anti-frost properties. X-ray photoelectron spectroscopy (XPS), ellipsometry and atomic force microscopy (AFM) were respectively used to determine the interfacial elemental composition, the thickness and the morphology of the brushes. The wettability of the polymer brushes was measured using a water contact angle goniometer. Their anti-fog and anti-frost capabilities were determined visually and tested quantitatively by UV-vis spectroscopy. The results indicated that the optical transmittance of substrates modified with superhydrophilic polymer coatings under both hot and cold fogging conditions was very high. Additionally, no visible frost was formed on the superhydrophilic substrates after storage in a freezer at -20 o C for the duration of the experiment. These results convincingly demonstrated that the resistance of the modified substrates to fogging and frosting is strongly correlated to the surface wettability. Moreover, there is no considerable difference in the performance of pSBMA and pSBVI polymer brushes, but the former is preferred because SBMA monomer is commercially available and requires short polymerization time to obtain superhydrophilicity.

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Surface charge control for zwitterionic polymer brushes: Tailoring surface properties to antifouling applications

Cited by 133 publications

References 62 publications

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Controlling cell adhesion using layer-by-layer approaches for biomedical applications

Surface-Attached Poly(oxanorbornene) Hydrogels with Antimicrobial and Protein-Repellent Moieties: The Quest for Simultaneous Dual Activity

Zwitterionic polymer brush coatings with excellent anti-fog and anti-frost properties

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