Surface activity and aggregation of pristine and hydrophobically modified inulin

Morros, Jordi; Infante, M. R.

doi:10.1039/c2sm26766g

Cited by 15 publications

(16 citation statements)

References 37 publications

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“…Particularly, previous reports declared that "The smaller aggregates, which in the case of inulins can be classifi ed as monomers and in the case of HMI as micelles, have dimensions below 15 nm." [ 53 ] It should be noted that in a previous work the size of INVITE 1 and INVITE 2 micelles were larger with respect to the present work. [ 31 ] This can be explained using the different applied method for micelles preparation.…”

Section: Size Stability Studies In Water By Dlscontrasting

confidence: 66%

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In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Catenacci

Mandracchia

Sorrenti

et al. 2014

Macro Chemistry & Physics

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H NMR is a suitable method to clarify the kind of interactions leading to the self-assembly of amphiphilic polymers. This work shows, from 1 H NMR studies performed in solution, that the self-assembly ability of the synthesized Inulin-D -α-tocopherol succinate (INVITE) amphiphilic polymers, can be addressed to specifi c π-π interactions between the aromatic regions of D -α-tocopherol. This result suggests the use of INVITE systems for the preferential loading of aromatic group bearing drugs such as curcumin. The preparation conditions, effect of drug loading, and lyophilization on the INVITE systems are evaluated by DSC and thermogravimetric analysis (TGA) analysis to assess whether common pharmaceutical processes could infl uence the physical properties of the amphiphilic polymers, such as crystallinity, glass-transition temperature or thermal degradation, to predict the physical stability of the systems upon administration. Furthermore, the size stability of the micelle systems up to 60 days is monitored to assess the feasibility of the INVITE micelles' long-term storage upon reconstitution with water.

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Section: Size Stability Studies In Water By Dlscontrasting

confidence: 66%

“…These data are consistent with the dimensions found for other micellar systems from hydrophobically modified Inulin (HMI). Particularly, previous reports declared that “The smaller aggregates, which in the case of inulins can be classified as monomers and in the case of HMI as micelles, have dimensions below 15 nm.”…”

Section: Resultsmentioning

confidence: 99%

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Catenacci

Mandracchia

Sorrenti

et al. 2014

Macro Chemistry & Physics

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“…20,21 The instrumentally smeared experimental SAXS curves were tted to numerical models, convoluted with beam size and detector width effects. 22 A least squares routine based on the LevenbergMarquardt scheme was used. 23 The bilayer thickness was determined using a three-Gaussian prole based on the MCG model according to Pabst et al 24,25 Dynamic light scattering (DLS)…”

Section: Potentiometric Measurementsmentioning

confidence: 99%

Characterization and stability of catanionic vesicles formed by pseudo-tetraalkyl surfactant mixtures

2014

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The phase behavior of an ad hoc synthesized surfactant, sodium 8-hexadecylsulfate (8-SHS), and its mixtures with didecyldimethylammonium bromide (DiDAB) in water is reported. We dealt with dilute concentration regimes, at a total surfactant content of <30 mmol kg(-1) where vesicular aggregates may be formed. The high synergistic behavior of such catanionic mixtures is concomitant with strongly negative interaction parameters, β (≈-18 kBT), significant gain in the free energy of association, ΔGagg, and much lower association concentration compared to the pure surfactants. Vesicle size and ζ-potential depend on the mixture composition. Hydrodynamic diameters increase by progressive addition of oppositely charged surfactants to the one in excess. Counter-intuitively, the ζ-potential becomes more negative at DiDAB molar fractions close to 0.2. The same holds in the reverse case, the ζ-potential becomes more positive after small additions of 8-SHS; anyhow, the effect is more significant in anionic-rich mixtures. This phenomenon was explained by assuming a significant release of counterions and an asymmetric distribution of the two surfactants in the inner and outer vesicle leaflets. The equimolar mixtures form a cubic phase rather than the expected lamellar one. The effect of NaBr concentration on the stability of catanionic vesicles was also investigated. At high NaBr concentrations, all systems are destabilized. For DiDAB-rich vesicles, flocculation is observed, while for 8-SHS-rich ones, lamellar domains are formed at the bottom of the samples. The role played by NaBr depends on whether it is added before or after mixing the surfactants. In particular, preformed catanionic vesicles show a great kinetic stability towards addition of NaBr compared to those obtained by other procedures.

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“…36 Our home-made fitting routines allow for convolution of the theoretical curves with our experimental detector width smearing function and use a Leverberg-Marquad scheme for minimization. 37 In the fitting we have let free the area per molecule Am, the hydrophobic length Lc, and the hydrophilic length Lh. Using these, we have calculated the hydrophobic electron density ρc, the number of water molecules in the polar region Nw, and the hydrophilic electron density ρh.…”

Section: Fluorescence Spectroscopymentioning

confidence: 99%

Supramolecular Arrangement of Molybdenum Carbonyl Metallosurfactants with CO-Releasing Properties

Parera¹,

Marín-García²,

Pons

et al. 2016

Organometallics

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Two families of molybdenum carbonyl metallosurfactants, Mo(CO) 5 L and Mo(CO) 4 L 2 , were synthesized using the functionalized phosphines, Ph 2 P(CH 2 ) n SO 3 Na (n = 2, 6, 10) and characterized by the usual spectroscopic and spectrometric methods. The study of the supramolecular arrangements of these compounds in aqueous medium has been performed by surface tension, fluorescence, dynamic light scattering, cryo-TEM, and small angle X-ray scattering. All data points to the formation of medium and large vesicular structures with a membrane similar to the classical lipid bilayer, but it contains organometallic fragments instead of simple hydrophobic chains. Studies of CO releasing with these molybdenum carbonyl metallosurfactants have shown their viability as a promising CO releasing molecules.

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Surface activity and aggregation of pristine and hydrophobically modified inulin

Cited by 15 publications

References 37 publications

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Characterization and stability of catanionic vesicles formed by pseudo-tetraalkyl surfactant mixtures

Supramolecular Arrangement of Molybdenum Carbonyl Metallosurfactants with CO-Releasing Properties

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Surface activity and aggregation of pristine and hydrophobically modified inulin

Cited by 15 publications

References 37 publications

In‐Solution Structural Considerations by 1H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

In‐Solution Structural Considerations by 1H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

Characterization and stability of catanionic vesicles formed by pseudo-tetraalkyl surfactant mixtures

Supramolecular Arrangement of Molybdenum Carbonyl Metallosurfactants with CO-Releasing Properties

Contact Info

Product

Resources

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In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs

In‐Solution Structural Considerations by ¹H NMR and Solid‐State Thermal Properties of Inulin‐d‐α‐Tocopherol Succinate (INVITE) Micelles as Drug Delivery Systems for Hydrophobic Drugs