“…The difference in efficacy is striking; the percentage of recurrence of flutter in the amiodarone group agrees with the results obtained with this drug in patients with AF (Ϸ30%), 2,16,29 -34 whereas the number of recurrences in the RFA group is the same as that reported after cavotricuspid isthmus bidirectional block validation (Ͻ5%). 2,4,[7][8][9][10] The percentage of recurrence of AFL after a first episode is not well known because of the lack of evaluation of medical therapy versus placebo in a large AFL population. 5 Crijns et al 20 reported that the percentages of patients in sinus rhythm after a single cardioversion, without prophylactic antiarrhythmic drugs, were 53%, 47%, and 42% after 0.5, 1, and 5 years, respectively, in a population of 50 consecutive patients.…”