Supramolecular salicylic acid ameliorates rosacea-like eruptions by suppressing NLRP3-mediated inflammasome activation in mice

Wang, JingYu; Sun, Yan; Chen, LiangHong; Wang, YiChong; Shi, DongXin; Wu, Yan; Gao, Xinghua

doi:10.1016/j.intimp.2023.110057

Cited by 4 publications

(1 citation statement)

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“…Another medication with therapeutic potential around the cathelicidin pathway is supramolecular salicylic acid (SSA). Studies have demonstrated that SSA displays keratolytic, antibacterial, and anti-inflammatory properties and is currently under research for efficacy in rosacea ( 100 ). The therapy is hypothesized to take effect through suppression NF-kβ and inhibition of assembly of the NLRP3 inflammasome ( 24 , 101 ).…”

Section: Future Therapies and Rational Targetsmentioning

confidence: 99%

Rosacea pathogenesis and therapeutics: current treatments and a look at future targets

Fisher,

Travers,

Rohan

2023

Front. Med.

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Rosacea is a chronic inflammatory skin condition associated with a significant health and economic burden from costs and loss of productivity due to seeking medical treatment. The disease encompasses multiple phenotypic manifestations involving a complex and multi-variate pathogenesis. Although the pathophysiology of rosacea is not completely understood, ongoing research is continually elucidating its mechanisms. In this review, current concepts of rosacea pathogenesis will be addressed which involve skin barrier and permeability dysfunction, the innate and adaptive immune systems, and the neurovascular system. More specifically, the cathelicidin pathway, transient potential receptor channels, mast cells, and the NLRP3 inflammasome pathway are various targets of current pharmacologic regimens. Future therapies may seek different mechanisms to act on current treatment targets, like the potential use of JAK/STAT inhibitors in ameliorating skin barrier dysfunction or TLR antagonists in alleviating cathelicidin mediated inflammation. Other potential treatments aim for entirely different molecular targets such as microvesicle particle mediated local and systemic inflammation. Ultimately rosacea is associated with a significant health and economic burden which warrants deeper research into its pathogenesis and resultant new treatment discovery.

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Section: Future Therapies and Rational Targetsmentioning

confidence: 99%