Supramolecular Chirality: Solvent Chirality Transfer in Molecular Chemistry and Polymer Chemistry

Abstract

Controlled mirror symmetry breaking arising from chemical and physical origin is currently one of the hottest issues in the field of supramolecular chirality. The dynamic twisting abilities of solvent molecules are often ignored and unknown, although the targeted molecules and polymers in a fluid solution are surrounded by solvent molecules. We should pay more attention to the facts that mostly all of the chemical and physical properties of these molecules and polymers in the ground and photoexcited states are significantly influenced by the surrounding solvent molecules with much conformational freedom through non-covalent supramolecular interactions between these substances and solvent molecules. This review highlights a series of studies that include: (i) historical background, covering chiral NaClO 3 crystallization in the presence of D-sugars in the late 19th century; (ii) early solvent chirality effects for optically inactive chromophores/fluorophores in the 1960s-1980s; and (iii) the recent development of mirror symmetry breaking from the corresponding achiral or optically inactive molecules and polymers with the help of molecular chirality as the solvent use quantity.

The Chain of Chirality Transfer as Determinant of Brain Functional Laterality. Breaking the Chirality Silence: Search for New Generation of Biomarkers; Relevance to Neurodegenerative Diseases, Cognitive Psychology, and Nutrition Science

“…Sensitivity of Chirality Transfer to Internal, External, Local and Global Conditions Symmetry transformation arising from chemical and physical origin is one of the hottest issues in the field of molecular chirality [5][6][7][8]. Before the further consideration it is essential to emphasize that hypothesis about the distinction between internal and external determinates in the living organism being very productive could become irrational in the form of an absolute opposition.…”

“…"Chirality plays a fundamental role in the activity of biological molecules and broad classes of chemical reactions" [5]. "Controlled mirror symmetry breaking arising from chemical and physical origin is currently one of the hottest issues in the field of supramolecular chirality" [6]. "Chiral recognition is the fundamental property of many biological molecules" [7].…”

Untitled

“…Yet it is conceivable that solvent water containing H 2 O ordered in chiral structures sets off mirror-symmetry breaking. Some solvents cause such asymmetry (6,7). For example, optical inactive benzyl and benzophenone when dissolved in levorotatory 2,3-butanediol exhibit optical activity in the n → π* carbonyl absorption (8), presumable because of hydrogen bonding between the solvent and the carbonyl group.…”

Enantiopure Chiral Coordination Polymers Based on Polynuclear Paddlewheel Helices and Arsenyl Tartrate

“…Specifically, chiral Coordination Polymers (CPs) offer a great potential in the context of numerous fields such as enantioselective catalysis [1][2][3][4], nonlinear optics [5,6], ferroelectricity [7], and magnetochiral dichroism [8]. Such enantiopure complexes can be obtained fortuitously by spontaneous resolution during crystallization [9,10] or by design, using chiral ligands, metalloligands [11][12][13], or chiral inductors, such as solvents, templates, or counteranions [14][15][16]. However, and despite the progress made in this direction, rational preparation of chiral CPs still presents a challenge in coordination chemistry.…”