Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion

Abstract

ObjectiveTo analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions.MethodsClinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization. Survival analysis was performed by Kaplan-Meier analysis, factors were compared using log-rank test, and prognostic factors were determined using Cox proportional hazards model. The relationship between subregions and clinicopathologic factors was analyzed using Chi-square tests.ResultsHPV prevalence differed between patients with aryepiglottic fold carcinoma and ventricle carcinoma (P < .05). The local-regional control rates, overall survival rates or cancer specific survival rates were significantly different between different subregions. Univariate analysis indicated that pTNM classification, pN spread, and subregion were associated with prognosis (P < .05). Multivariate analysis indicated that pTNM classification and subregion were associated with supraglottic carcinoma prognosis. The survival rate was better for patients with carcinoma of the epiglottis or ventricular bands compared to those with carcinoma in the aryepiglottic fold or ventricle (P = .012).ConclusionsSubregion may be a new prognostic factor for supraglottic squamous cell carcinoma. Different supraglottic carcinoma subregions have distinct clinical features such as HPV expression, lymph node metastasis rate, local-regional control and prognosis. Therefore, it is necessary to subdivide supraglottic squamous cell carcinomas into several subregion groups to individualize therapy.

Three-in-one: case of multiple primary malignancies concurrently in a 70 year-old female

“…1 Among the supraglottic regions, the epiglottis has a 14.8% rate of expression. 5 There is also a higher percentage of p16 expression at 86.6% of HPV+ patients compared to 2.9% for p18 expression. 5 Breast cancer has 20 different histologic types with invasive ductal carcinoma (IDC) being the most common at 80% prevalence and invasive lobular carcinoma at 5-15%.…”

“…5 There is also a higher percentage of p16 expression at 86.6% of HPV+ patients compared to 2.9% for p18 expression. 5 Breast cancer has 20 different histologic types with invasive ductal carcinoma (IDC) being the most common at 80% prevalence and invasive lobular carcinoma at 5-15%. 2 ILC tends to be more bilateral, multifocal, larger tumors, high ER and PR expression and lower HER expression compared to IDC.…”

Artificial intelligence in tumor subregion analysis based on medical imaging: A review

“…Ding et al investigated the clinicopathological characteristics of different supraglottic subregions and their correlation with the prognosis of patients with squamous cell carcinoma. 39 Supraglottic squamous cell carcinomas were divided into four types based on subregion: epiglottis, ventricular bands, aryepiglottic fold, and ventricle. A Cox proportional hazards model was used to generate a biomarker.…”

“…Table 1 shows a list of selected studies that used supervised learning for tumor subregion analysis in the head and neck. Ding et al investigated the clinicopathological characteristics of different supraglottic subregions and their correlation with the prognosis of patients with squamous cell carcinoma 39 . Supraglottic squamous cell carcinomas were divided into four types based on subregion: epiglottis, ventricular bands, aryepiglottic fold, and ventricle.…”

Modelos de predição de risco de morte para pacientes com carcinoma epidermoide de cabeça e pescoço

“…Tabela 76 -Teste "goodness-of-fit" -modelo de regressão logística para tumores de laringe. (134). Contudo, foi difícil utilizar esta informação.…”