Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment

Gaetti‐Jardim, Elerson; Jardim, Éllen Cristina Gaetti; Schweitzer, Christiane Marie; Silva, Julio Cesar Leite da; Oliveira, Murilo Moura; Masocatto, Danilo Chizzolini; Santos, Claudiana Moura dos

doi:10.1016/j.archoralbio.2018.01.003

Cited by 40 publications

(42 citation statements)

References 20 publications

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“…1,2,16 In addition, one study is from the American continent, more specifically Brazil. 5 The microbial analysis of OM articles…”

Section: Resultsmentioning

confidence: 99%

“…The studies selected had used different methodologies, both those of conventional culture with the microorganisms being analyzed by cultures in selective media, 3,5,[12][13][14][15] as microbial analysis by 16S sequencing. 1,2,11 Six studies have analyzed bacteria and two studies analyzed mainly fungi.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3][11][12][13][14][15] One study analyzed both microbiological groups. 5 The kind of sample of OM articles From the nine manuscript selected, three studies collected the sample with oropharyngeal swab before and after RT. 2,13,15 One study collected the supragingival plaque before and after CT. 14 One study collected the supra and subgingival plaque before and after RT.…”

Section: Resultsmentioning

confidence: 99%

“…4 Its symptoms of pain, difficulty in swallowing, trismus and decreased taste, detract from the nutrition of the patient, therefore, the predisposition to microbial virulence factors is greater, compromising the general state of health. 1,5 In fact, the oral microbiota has been implicated as an agent of progression and/or aggravation of the OM for years. 3,[6][7] Despite there are no effective interventions for…”

Section: Introductionmentioning

confidence: 99%

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Oral microbiota versus oral mucositis during cancer treatment: a review

Ribeiro¹,

Ferigatto²,

César³

et al. 2020

hu rev

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Introduction: Oral microbiota has been implicated on oral mucositis (OM) that occurs during cancer therapy, however without consensus. Objective: This study, aimed to establish, through a review, the association between oral microbiota and OM at head and neck cancer therapy (HNCT). Material and methods: The search of PubMed was performed considering 2008-2018 period, and the descriptors “oral mucositis” and “oral microbiota” in subheadings etiology and microbiology into the Medical Subject Heading (MeSH) “Head and Neck Neoplasms”. The conducting question was “Is there an oral dysbiosis during HNCT associated with OM?”. Results: 22 articles were selected under two steps of data extraction: articles that evaluated de oral microbiota during HNCT (n=13), and articles that also focused in OM (n=9). Conclusion: The evidence presented in the literature suggests associations of oral microbiota dysbiosis with the progression and worsening of radiation-induced OM. However, to define a microbial core for the disease, future standardized studies are required.

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“…1,2,16 In addition, one study is from the American continent, more specifically Brazil. 5 The microbial analysis of OM articles…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oral microbiota versus oral mucositis during cancer treatment: a review

Ribeiro¹,

Ferigatto²,

César³

et al. 2020

hu rev

View full text Add to dashboard Cite

show abstract

“…Other work only sampled a single supragingival surface 56 . Of the studies that did sample multiple sites, such as the maxillary and mandibular molars, samples were pooled before analysis [57][58][59] , or summary data were reported for whole mouths rather than site-specific data 60,61 . To our knowledge the first study to examine spatial variability (two interproximal sites, anterior vs. posterior) in cultivable Lactobacillus populations, did so by studying Sjögren syndrome patients, and provided the first evidence in support of the hypothesis that reduced salivary flow remodels the spatial organization of oral microbial communities 62 .…”

Section: Spatial Patterns Of Dental Caries and The Supragingival Micrmentioning

confidence: 99%

Microbial biogeography and ecology of the mouth and implications for periodontal diseases

Proctor

Shelef

González

et al. 2019

Preprint

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Human-associated microbial communities differ in composition among body sites and between habitats within a site. Patterns of variation in the distribution of organisms across time and space is referred to as 'biogeography'. The human oral cavity is a critical observatory for exploring microbial biogeography because it is spatially structured, easily accessible, and its microbiota has been linked to the promotion of both health and disease. The biogeographic features of microbial communities residing in spatially distinct but ecologically similar environments on the human body, including the subgingival crevice, have not yet been adequately explored. The purpose of this paper is twofold. First, we seek to provide the dental community with a primer on biogeographic theory, highlighting its relevance to the study of the human oral cavity. For this reason, we summarize what is known about the biogeographic variation of dental caries and periodontitis and postulate as to how this may be driven by spatial patterning in oral microbial community composition and structure. Second, we present a number of methods that investigators can use to test specific hypotheses using biogeographic theory.To anchor our discussion, we apply each method to a case study and examine the spatial variation of the human subgingival microbiota of 2 individuals. Our case study suggests that subgingival communities in the aggregate may conform to an anterior-to-posterior gradient in community composition. The gradient appears to be structured both by deterministic and nondeterministic processes, though additional work is needed to test and confirm specific hypotheses. A better understanding of biogeographic patterns and processes will advance our understanding of ways to optimize the efficacy of dental interventions targeting the oral microbiota.

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Redox‐Activatable Magnetic Nanoarchitectonics for Self‐Enhanced Tumor Imaging and Synergistic Photothermal‐Chemodynamic Therapy

Zheng,

Wang,

et al. 2023

Small Methods

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Oral squamous cell carcinoma (OSCC) is a prevalent malignancy of the head and neck region associated with high recurrence rates and poor prognosis under current diagnostic and treatment methods. The development of nanomaterials that can improve diagnostic accuracy and therapeutic efficacy is of great importance for OSCC. In this study, a redox‐activatable nanoarchitectonics is designed via the construction of dual‐valence cobalt oxide (DV‐CO) nanospheres, which can serve as a contrast agent for magnetic resonance (MR) imaging, and exhibit enhanced transverse and longitudinal relaxivities through the release and redox of Co3+/Co2+ in an acidic condition with glutathione (GSH), resulting in self‐enhanced T1/T2‐weighted MR contrast. Moreover, DV‐CO demonstrates properties of intracellular GSH‐depletion and hydroxyl radicals (•OH) generation through a Fenton‐like reaction, enabling strengthened chemodynamic (CD) effect. Additionally, DV‐CO displays efficient near‐infrared laser‐induced photothermal (PT) effect, thereby exhibiting synergistic PT‐CD therapy for suppressing OSCC tumor cells. It further investigates the tumor‐specific self‐enhanced MR imaging of DV‐CO both in subcutaneous and orthotopic OSCC mouse models, and demonstrate the therapeutic effects of DV‐CO in orthotopic OSCC mouse models. Overall, the in vitro and in vivo findings highlight the excellent theranositc potentials of DV‐CO for OSCC and offer new prospects for future advancement of nanomaterials.

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Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment

Abstract: Modifications in oral biofilms of irradiated patients showed association with xerostomia and hygiene conditions, which reinforces the necessity of improving patient compliance to oral health care programs.

Cited by 40 publications

References 20 publications

Oral microbiota versus oral mucositis during cancer treatment: a review

Oral microbiota versus oral mucositis during cancer treatment: a review

Microbial biogeography and ecology of the mouth and implications for periodontal diseases

Redox‐Activatable Magnetic Nanoarchitectonics for Self‐Enhanced Tumor Imaging and Synergistic Photothermal‐Chemodynamic Therapy

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