volume 191, issue 9, P4656-4664 2013
DOI: 10.4049/jimmunol.1300450
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José M. Duhart, María Juliana Leone, Natalia Paladino, Jennifer A. Evans, Oscar Castanon-Cervantes, Alec J. Davidson, Diego A. Golombek

Abstract: The immune and the circadian systems interact in a bidirectional fashion. The master circadian oscillator, located in the suprachiasmatic nuclei of the hypothalamus (SCN), responds to peripheral and local immune stimuli, such as proinflammatory cytokines and bacterial endotoxin. Astrocytes exert several immune functions in the central nervous system and there is growing evidence that points towards a role of these cells in the regulation of circadian rhythms. The aim of this work was to assess the response of…

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