SUPPRESSIVE EFFECT OF PROSTAGLANDIN (PG)D<sub>2</sub>ON PULSATILE LUTEINIZING HORMONE RELEASE IN CONSCIOUS CASTRATED RATS

Kinoshita, Fumko; Nakai, Yoshikatsu; Katakami, Hideki; Imura, Hiroo; Shimizu, Takao; Hayaishi, Osamu

doi:10.1210/endo-110-6-2207

Cited by 66 publications

(24 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wogensen and Warberg [17] reported that PGD 2 was capable of stimulating the release of LH in intact and castrated anesthetized male rats in vivo, whereas no effect was observed on the release of PRL. On the other hand, Kinoshita et al [21] found depressions in pulsatile LH release and in mean LH levels in conscious castrated male rats following intraventricular administrations of PGD 2 .…”

Section: Discussionmentioning

confidence: 98%

Effects of Prostaglandins E2, F2.ALPHA., and D2 on the Release of Growth Hormone, Prolactin, and Luteinizing Hormone from Cultured Bovine Anterior Pituitary Cells.

Hashizume

Kanematsu

1995

Journal of Reproduction and Development

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Effects of Prostaglandins E2, F2.ALPHA., and D2 on the Release of Growth Hormone, Prolactin, and Luteinizing Hormone from Cultured Bovine Anterior Pituitary Cells.

Hashizume

Kanematsu

1995

Journal of Reproduction and Development

View full text Add to dashboard Cite

“…The intraventricular administration of prostaglandin D 2 inhibits luteinizing hormone secretion (39). Consistently, GC is known to suppress gene expression of gonadotropin-releasing hormone (5) and inhibit testicular steroidogenesis (4).…”

Section: Differentially Expressed Transcripts Involved In Metabolismmentioning

confidence: 95%

Regulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis

Nishida

Yoshioka

St‐Amand

2006

Physiological Genomics

View full text Add to dashboard Cite

Using the serial analysis of gene expression (SAGE) method, we studied the effects of adrenalectomy (ADX) and GC on the transcriptomes of mouse hypothalamus. Approximately 180,000 SAGE tags, which correspond to 50,000 tag species, were isolated from each group of intact or adrenalectomized mice as well as 1, 3, and 24 h after GC injection. ADX upregulated diazepam binding inhibitor gene expression while downregulating vomeronasal 1 receptor D4, genes involved in mitochondrial phosphorylation (cytochrome-c oxidase 1 and NADH dehydrogenase 3), 3␤-hydroxysteroid dehydrogenase-1, and prostaglandin D2 synthase. GC increased the gene expression levels of dehydrogenase/reductase member 3, prostaglandin D2 synthase, solute carrier family 4 member 4, and five cytoskeletal proteins including myosin light chain phosphorylatable fast and troponin C2 fast. On the other hand, GC reduced the mRNA levels of calmodulin 1 and expressed sequence tag similar to calmodulin 2, ATP synthase F0 subunit 6, and solute carrier family 4 member 3. Moreover, 7 uncharacterized and 43 novel transcripts were modulated by ADX and GC. The present study has identified genes that may regulate hypothalamic systems governing energy balance in response to ADX and GC.transcriptome; serial analysis of gene expression; adrenalectomy; obesity CLINICAL FEATURES OF ANOREXIA and weight loss in patients with adrenal insufficiency as well as increased food intake and weight gain in patients with glucocorticoid (GC) excess implicate adrenal GC in energy homeostasis (18). Obesity is dependent on GC action, because rodent models of obesity with pathologies of genetic (13), dietary (65), and hypothalamic (38) origins are normalized by adrenalectomy (ADX) and restored by GC replacement (27). In normal rodents and humans, GC increases food intake and body weight, as well as inducing metabolic features of obesity, such as insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hyperleptinemia (30, 76). Interestingly, an administration of leptin, which barely affects body weight and food intake, becomes powerful and long-lasting in ADX rats, suggesting that GC antagonizes the central action of leptin (75). GC not only increases food intake but also decreases energy expenditure by suppressing thermogenesis in mouse brown adipose tissue (63). Thus GC promotes positive energy balance, whereas a lack of GC is linked to hypophagia and reduced body weight.The hypothalamus is a brain center that regulates energy homeostasis by integrating peripheral signals such as leptin, insulin, and GC. Thus the effects of ADX and GC on hypothalamic gene expression have been a major focus of many previous studies (45,54,60,73). However, no study has previously investigated effects of ADX and GC in the transcriptome of the hypothalamus. The serial analysis gene expression (SAGE) method accurately measures the expression levels of tens of thousands of genes, previously known or not, and finds the genes related to diseases or the effects of stimuli (59,68). Although other techniques ...

show abstract

“…Synthesis of PGD2 in the brain is induced by certain stimuli such as seizure and transient cerebral ischemia (Birkle and Bazan, 1987;Leifke et al, 1994). In the central nervous system, PGD2 exerts a variety of functions such as sleep induction (Ueno et al, 1983;Hayaishi, 1991;Urade et al, 1996) and regulation of body temperature (Ueno et al, 1982;Moritomo et al, 1988;Sri Kantha et al, 1994), hormone release (Kinoshita et al, 1982;Nishi et al, 1984;Terao et a!., 1995), and nociception (Horiguchi et a!., 1992;Minami et al, 1996). In the eye, PGD2 has been implicated in the regulation of intraocular pressure (Goh et al, 1988;Woodward et al, 1990Woodward et al, , 1993Bazan and Allan, 1997).…”

mentioning

confidence: 99%

Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes

Gerashchenko

Beuckmann

Kanaoka

et al. 1998

Journal of Neurochemistry

Self Cite

View full text Add to dashboard Cite

Prostaglandin (PG) D 2 is one of the major prostanoids in the mammalian brain and eye tissues. Its function is mediated by the prostanoid DP receptor, which is specific for PGD2 among the various prostanoids. In this study, we cloned the full-length cDNA for the rat DP receptor and used it for detection of DP receptor mRNA in various rat tissues. Northern blotting and RT-PCR analyses revealed that this DP receptor was expressed most intensely in the eye tissues, moderately in the leptomeninges and oviduct, and weakly in the epididymis. The tissue distribution profile of the mRNA for the rat DP receptor is overlapped with those of hematopoietic and lipocalin-type PGD synthases. Among rat eye tissues, the expression was the highest in the iris. In situ hybridization and in situ RT-PCR revealed DP receptor mRNA to be localized in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina, suggesting the involvement of the receptor in the physiological regulation of intraocular pressure and the vision process. In the brain, DP receptor mRNA was dominantly expressed in the leptomeninges and was not detected in the brain parenchyma including the ventral rostral forebrain, the surface area of which is reportedly involved in sleep induction by PGD2.

show abstract

SUPPRESSIVE EFFECT OF PROSTAGLANDIN (PG)D₂ON PULSATILE LUTEINIZING HORMONE RELEASE IN CONSCIOUS CASTRATED RATS

Cited by 66 publications

References 10 publications

Effects of Prostaglandins E2, F2.ALPHA., and D2 on the Release of Growth Hormone, Prolactin, and Luteinizing Hormone from Cultured Bovine Anterior Pituitary Cells.

Effects of Prostaglandins E2, F2.ALPHA., and D2 on the Release of Growth Hormone, Prolactin, and Luteinizing Hormone from Cultured Bovine Anterior Pituitary Cells.

Regulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis

Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes

Contact Info

Product

Resources

About

SUPPRESSIVE EFFECT OF PROSTAGLANDIN (PG)D2ON PULSATILE LUTEINIZING HORMONE RELEASE IN CONSCIOUS CASTRATED RATS

Cited by 66 publications

References 10 publications

Effects of Prostaglandins E2, F2.ALPHA., and D2 on the Release of Growth Hormone, Prolactin, and Luteinizing Hormone from Cultured Bovine Anterior Pituitary Cells.

Effects of Prostaglandins E2, F2.ALPHA., and D2 on the Release of Growth Hormone, Prolactin, and Luteinizing Hormone from Cultured Bovine Anterior Pituitary Cells.

Regulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis

Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes

Contact Info

Product

Resources

About

SUPPRESSIVE EFFECT OF PROSTAGLANDIN (PG)D₂ON PULSATILE LUTEINIZING HORMONE RELEASE IN CONSCIOUS CASTRATED RATS