Biochemical Pharmacology volume 81, issue 11, P1263-1270 2011 DOI: 10.1016/j.bcp.2011.03.003 View full text
Huan-Chih Chiu, Ding-Li Chou, Chin-Ting Huang, Wen-Hsing Lin, Tzu-Wen Lien, Kuei-Jung Yen, John T.-A. Hsu

Abstract: Epidermal growth factor receptor (EGFR) is a proven therapeutic target to treat a small subset of non small cell lung cancer (NSCLC) harboring activating mutations within the EGFR gene. However, many NSCLC patients are not sensitive to EGFR inhibitors, suggesting that other factors are implicated in survival of NSCLC cells. Signal transducers and activators of transcription 3 (Stat3) function as transcription factor to mediate cell survival and differentiation and the dysregulation of Stat3 has been discovered…

expand abstract