Suppression of Movement Disorders by Jaw Realignment

Sims, Anthony B.; Clark, Vincent P.; Cooper, Mark S.

doi:10.1111/j.1526-4637.2012.01364.x

Cited by 4 publications

(3 citation statements)

References 10 publications

(10 reference statements)

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“…The movement disorder symptoms of the above patient have important similarities to certain cases reported by Sims et al (2012) (see Movies S3 (fixed dystonia that remits) and S4 (paroxysmal dystonic attacks) in this paper). These cases, as well as the specific pattern of progression of symptoms in the above case of idiopathic symptomatic hyperekplexia, may involve migration of neuroinflammation from sites of peripheral nerve injury into the brainstem.…”

Section: Introductionsupporting

confidence: 84%

“…Several papers have documented the onset of cranial dystonias following dental procedures or other trauma to tissues in the oral cavity (Sankhla et al 1998; Schrag et al 1999). Migration of neuroinflammation from an injured branch of the trigeminal nerve into first-order and second-order synapses located in the brainstem might serve as drivers for the genesis of such movement disorders (Sims et al 2012). …”

Section: Introductionmentioning

confidence: 99%

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Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Cooper

Clark

2012

J Neuroimmune Pharmacol

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Complex Regional Pain Syndrome (CRPS) is associated with non-dermatomal patterns of pain, unusual movement disorders, and somatovisceral dysfunctions. These symptoms are viewed by some neurologists and psychiatrists as being psychogenic in origin. Recent evidence, however, suggests that an autoimmune attack on self-antigens found in the peripheral and central nervous system may underlie a number of CRPS symptoms. From both animal and human studies, evidence is accumulating that neuroinflammation can spread, either anterograde or retrograde, via axonal projections in the CNS, thereby establishing neuroinflammatory tracks and secondary neuroinflammatory foci within the neuraxis. These findings suggest that neuroinflammatory lesions, as well as their associated functional consequences, should be evaluated during the differential diagnosis of non-dermatomal pain presentations, atypical movement disorders, as well as other “medically unexplained symptoms”, which are often attributed to psychogenic illness.

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Section: Introductionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Cooper

Clark

2012

J Neuroimmune Pharmacol

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“… 49 TMJ disc displacement may compress the mandibular nerve, causing neuropathic pain. 50 People with TMDs are more likely to have severe tinnitus and vertigo, potentially due to the TMJ’s proximity to the inner ear. 51 The complex anatomy and associated symptoms can complicate diagnosis and make treatment difficult, 52 and the outcome of patients with neural and joint symptoms is inconsistent, often resulting in unsuccessful treatments.…”

Section: Pathologymentioning

confidence: 99%

Knee orthopedics as a template for the temporomandibular joint

Bielajew

Donahue

Espinosa

et al. 2021

Cell Reports Medicine

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Although the knee joint and temporomandibular joint (TMJ) experience similar incidence of cartilage ailments, the knee orthopedics field has greater funding and more effective end-stage treatment options. Translational research has resulted in the development of tissue-engineered products for knee cartilage repair, but the same is not true for TMJ cartilages. Here, we examine the anatomy and pathology of the joints, compare current treatments and products for cartilage afflictions, and explore ways to accelerate the TMJ field. We examine disparities, such as a 6-fold higher article count and 2,000-fold higher total joint replacement frequency in the knee compared to the TMJ, despite similarities in osteoarthritis incidence. Using knee orthopedics as a template, basic and translational research will drive the development and implementation of clinical products for the TMJ. With more funding opportunities, training programs, and federal guidance, millions of people afflicted with TMJ disorders could benefit from novel, life-changing therapeutics.

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Temporomandibular Joint Dysfunction, Trigeminal Nerve Inflammation, and Biomechanical Dental Treatments for the Suppression of Neurological and Neuropsychiatric Symptoms

Sims¹,

Demerjian²

2018

Temporomandibular Joint and Airway Disorders

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Suppression of Movement Disorders by Jaw Realignment

Cited by 4 publications

References 10 publications

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Neuroinflammation, Neuroautoimmunity, and the Co-Morbidities of Complex Regional Pain Syndrome

Knee orthopedics as a template for the temporomandibular joint

Temporomandibular Joint Dysfunction, Trigeminal Nerve Inflammation, and Biomechanical Dental Treatments for the Suppression of Neurological and Neuropsychiatric Symptoms

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