Suppression of host gene expression is associated with latent TB infection: a possible diagnostic biomarker
Ritah Nakiboneka,
Nicolo Margaritella,
Tonney Nyirenda
et al.
Abstract:The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB (ATB) patients is recommended as one of the ways to curtail TB incidence. However, there is a shortage of tools to accurately diagnose LTBI. We assessed the appropriateness of whole blood host transcriptomic markers (TM) to diagnose LTBI among household contacts of bacteriologically confirmed index cases compare… Show more
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