Suppression of artifacts in two-dimensional J spectroscopy

Bodenhausen, Geoffrey; Freeman, Ray; Turner, David L.

doi:10.1016/0022-2364(77)90016-6

Cited by 296 publications

(160 citation statements)

References 6 publications

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“…The linewidth is determined by the effective sample height h and the strength g D of the decoding gradient, while the position of the echo depends on the chemical shift X S of spin S. In units of frequency, the spectral resolution Dv 1 in the indirect domain is given by . If the band-selective p pulse is phase-shifted through x, y in the manner of EXORCYCLE [18], the sum of the signals corresponds to the part of the spectrum that is not affected by the p pulse, while the difference gives the region which is refocused.…”

Section: Theorymentioning

confidence: 99%

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Improving resolution in single-scan 2D spectroscopy

Pelupessy

Duma

Bodenhausen

2008

Journal of Magnetic Resonance

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Section: Theorymentioning

confidence: 99%

“…Since a single p pulse is applied, the peaks that are recovered appear along an ''anti-diagonal". By shifting the phase of the band-selective pulse through 90°, in the manner of EXORCYCLE [18], the folded peaks change their sign. Thus, the sum of the spectra in Fig.…”

Section: Theorymentioning

confidence: 99%

Improving resolution in single-scan 2D spectroscopy

Pelupessy

Duma

Bodenhausen

2008

Journal of Magnetic Resonance

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“…1 Two signal acquisitions are repeated at each phase encoding step with phase inversion; the phases used are s 09 , 09 tfor the saturation pulse, and s 09 , 1809 tfor both the excitation pulse and receiver. Figure 2 illustrates the``semikeyhole'' acquisition scheme.…”

Section: Magnetic Resonance In Medical Sciencesmentioning

confidence: 99%

Averaging Keyhole Pulse Sequence with Presaturation Pulses and EXORCYCLE Phase Cycling for Dynamic Contrast-Enhanced MRI

et al. 2004

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The purpose of this study was to design a keyhole pulse sequence for quantitative 2D dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) based on a spoiled gradient echo T 1 -weighted acquisition. Saturation recovery was applied to achieve a linear correlation between signal intensity and contrast agent concentration in an arterial input function (AIF) while simultaneously removing time-of-‰ight eŠect. To remove ghosting artifacts arising from incomplete presaturation, EXORCYCLE phase cycling with averaging was applied to the pulse sequence. RF spoiling by radiofrequency switching with the synthesizer can be combined with EXORCYCLE phase cycling. Images aŠected by the large diŠerence in signal intensity before and after contrast agent administration with the keyhole technique were improved by interleaving of peripheral lines of k-space with groups of central lines. Both peripheral and central lines were renewed during the dynamic scan. AIFs were obtained from the rat abdominal aorta with this keyhole sequence.

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“…The phase £ of the 7r( 1 H)-pulse is alternated between x and -x to compensate for deviations from the 180 0 flip angle and for off-resonance effects ( Fig. 14^; Bodenhausen et al 1977). The receiver phase is kept constant upon alternation of the phase £ (Fig.…”

Section: X-half-filter Elementsmentioning

confidence: 99%

Heteronuclear filters in two-dimensional [¹H, ¹H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions

Otting¹,

Wüthrich²

1990

Quart. Rev. Biophys.

355

184

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The use of heteronuclear filters enables the editing of complex 1H nuclear magnetic resonance (NMR) spectra into simplified subspectra containing a lesser number of resonance lines, which are then more easily amenable to detailed spectral analysis. This editing is based on the creation of heteronuclear two-spin or multiple-spin coherence and discrimination between protons that do or do not participate in these heteronuclear coherences. In principle, heteronuclear editing can be used in conjunction with one-dimensional or multidimensional 1H-NMR experiments for studies of a wide variety of low-molecular-weight compounds or macromolecular systems, and is implicitely applied in a wide range of heteronuclear NMR experiments with proton detection (e.g. Bax et al. 1983; Griffey & Redfield, 1987). In the present article we shall focus on the use of heteronuclear filters in two-dimensional (2D) [1H, 1H]-NMR experiments. The selection of the material covered was primarily motivated by its impact on the practice of protein structure determination in solution, and on NMR studies of intermolecular interactions with biological macromolecules. Section 2 surveys potential applications of heteronuclear filters in this area. The remainder of the article is devoted to an introduction of the theoretical principles used in heteronuclear filters, and to a detailed description of the experimental implementation of these measurements. In writing the review we tried to minimize redundancy with the recent article in Quarterly Review of Biophysics by Griffey & Redfield (1987) and to concentrate on experiments that were introduced during the period 1986–9.

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Suppression of artifacts in two-dimensional J spectroscopy

Cited by 296 publications

References 6 publications

Improving resolution in single-scan 2D spectroscopy

Improving resolution in single-scan 2D spectroscopy

Averaging Keyhole Pulse Sequence with Presaturation Pulses and EXORCYCLE Phase Cycling for Dynamic Contrast-Enhanced MRI

Heteronuclear filters in two-dimensional [¹H, ¹H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions

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Suppression of artifacts in two-dimensional J spectroscopy

Cited by 296 publications

References 6 publications

Improving resolution in single-scan 2D spectroscopy

Improving resolution in single-scan 2D spectroscopy

Averaging Keyhole Pulse Sequence with Presaturation Pulses and EXORCYCLE Phase Cycling for Dynamic Contrast-Enhanced MRI

Heteronuclear filters in two-dimensional [1H, 1H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions

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Heteronuclear filters in two-dimensional [¹H, ¹H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactions