Suppressed Bone Turnover in Obesity: A Link to Energy Metabolism? A Case-Control Study

Viljakainen, Heli; Ivaska, Kaisa K.; Paldánius, Päivi M.; Lipsanen‐Nyman, Marita; Saukkonen, Tero; Pietiläinen, Kirsi H.; Andersson, Sture; Laitinen, Kalevi; Mäkitie, Outi

doi:10.1210/jc.2013-3097

Cited by 63 publications

(52 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Follow-up studies are required to ascertain the causality. Excessive visceral fat clusters with insulin resistance and enhanced inflammatory status [30,31], and these are also known to affect bone metabolism [19,28]. Replacing BMI with waist circumference had only minor effect on our results, mostly on the weight-bearing site: several lifestyle factors appeared to be associated positively with tibial outcomes, suggesting that BMI catches the weight-bearing effects better than waist circumference.…”

Section: Discussionmentioning

confidence: 70%

“…Anthropometry including height (cm), weight (kg), and waist (WC; cm) and hip circumferences (cm) was collected during the study visit, as described previously [19]. Background data on education level (of the subjects and their parents) and clinical history including history of fractures and lifestyle factors were collected using a questionnaire.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Bone Characteristics and Their Determinants in Adolescents and Young Adults with Early-Onset Severe Obesity

et al. 2015

View full text Add to dashboard Cite

Childhood obesity is associated with compromised bone health. We studied bone characteristics and their determinants in obese young adults. The study included 68 subjects with early-onset severe obesity and 73 normal-weight controls. Data on physical activity (PA), diet and smoking were collected. Bone characteristics were measured using peripheral QCT. The obese and control subjects were similar in age (mean 19.6 ± 2.6 years) and height but BMIs differed (39.7 and 22.6 kg/m(2)). A clustering of unhealthy lifestyles was marked: Obese subjects reported less supervised PA in childhood, adolescence and currently (p < 0.03) and were more likely to smoke (p = 0.005), and had a lower healthy eating index (HEI) (p = 0.007) but similar alcohol consumption compared with controls. In obese women, all crude bone characteristics were higher than in controls; in men, the differences were smaller. Associations of lifestyle factors with bone characteristics were tested using partial correlations. Independently of BMI, supervised PA in adolescence and alcohol consumption were related positively to bone characteristics in both groups. HEI associated positively with bone characteristics only in controls, while smoking was a positive determinant of bone characteristics only in obese subjects. The multivariate model showed that the contribution of lifestyle factors to bone characteristics was minimal compared with BMI. Early-onset obesity is accompanied by poor dietary quality, sedentary lifestyle, and more frequent smoking, but the overall contribution of these lifestyle factors to bone strength is limited. Bone strength is more likely to be compromised in men and in unloaded bone sites in subjects with early-onset severe obesity. The impact of obesity-related endocrine changes on bone characteristics need to be evaluated in future studies.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Bone Characteristics and Their Determinants in Adolescents and Young Adults with Early-Onset Severe Obesity

et al. 2015

View full text Add to dashboard Cite

show abstract

“…We speculate that one of the reasons for this discrepancy in our data compared to previously published reports could be the elevated BMI in our GDM group. It has been suggested that obesity is associated with low bone turnover [27,28]; obese subjects demonstrate lower circulating osteocalcin compared with non-obese subjects, and some reports have described increases in OC in obese subjects after substantial weight loss with aerobic training or bariatric surgery [29,30]. To our knowledge, this would be the first study evaluating ucOC in GDM.…”

Section: Discussionmentioning

confidence: 79%

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

Saucedo

Rico

Vega

et al. 2014

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…In previous studies, OC concentration has been shown to correlate with testosterone concentration [17-19], but the results are inconsistent [35]. Lower OC concentrations in cases may merely reflect suppressed bone turnover in the obesity [23]. …”

Section: Discussionmentioning

confidence: 99%

“…The study was designed to assess skeletal and metabolic characteristics of severe childhood-onset obesity at young adulthood and was carried out at Children’s Hospital, Helsinki University Central Hospital, Finland as previously reported [23]. In the present study assessing testicular function, inclusion criteria for the patients with early-onset severe obesity were: (i) males with age- and sex-adjusted body mass index (BMI) corresponding to severe obesity (BMI > 35 in adult males) before the age of 9 years, according to Finnish growth standards [24], (ii) referral because of severe obesity to Children’s Hospital, Helsinki University Hospital, during childhood, (iii) living in the capital region of Helsinki at age 9 years, and (iv) aged between 15 and 25 years at the time of the study.…”

Section: Methodsmentioning

confidence: 99%

Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity

Laakso

Viljakainen²,

Lipsanen‐Nyman

et al. 2018

Horm Res Paediatr

Self Cite

View full text Add to dashboard Cite

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes, and skeleton at late puberty. Methods: A cohort of adolescent and young adult males with severe childhood-onset obesity (n = 21, mean age 18.5 years) and an age-matched control group were assessed for testicular hormones and X-ray absorptiometry-derived bone mass. Results: Current median body mass indexes for the obese and control subjects were 37.4 and 22.9. Severe early-onset obesity manifested with lower free testosterone (median [interquartile range] 244 [194–332] vs. 403 [293–463] pmol/L, p = 0.002). Lower insulin-like 3 (1.02 [0.82–1.23] vs. 1.22 [1.01–1.46] ng/mL, p = 0.045) and lower ratio of testosterone to luteinizing hormone (2.81 [1.96–3.98] vs. 4.10 [3.03–5.83] nmol/IU, p = 0.008) suggested disrupted Leydig cell function. The degree of current obesity inversely correlated with free testosterone (τ = –0.516, p = 0.003), which in turn correlated positively with bone area at all measurement sites in males with childhood-onset obesity. Conclusions: Severe childhood-onset obesity is associated with impaired Leydig cell function in young men and lower free testosterone may contribute to impaired skeletal characteristics.

show abstract

Suppressed Bone Turnover in Obesity: A Link to Energy Metabolism? A Case-Control Study

Cited by 63 publications

References 51 publications

Bone Characteristics and Their Determinants in Adolescents and Young Adults with Early-Onset Severe Obesity

Bone Characteristics and Their Determinants in Adolescents and Young Adults with Early-Onset Severe Obesity

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity

Contact Info

Product

Resources

About