Supposed role of “Metabolic memory” in formation of response reaction to stress factors in young and adult organisms

Божков, А. И.; Dlubovskaya, V. L.; Dmitriev, Yu. V.; Meshaikina, N. I.; Maleev, V. A.; Klimova, E. M.

doi:10.1134/s2079057011010048

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…The ability to choose different adaptation strategies is the result of multifunctionality and hierarchy of biological systems [3]. We believe that the choice of adaptation strategies will determine the features of the development of chronic pathologies, the rate of aging and, as a result, the life span.…”

Section: Introductionmentioning

confidence: 99%

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Ai¹,

Yu²

2016

J Gerontol Geriatr Res

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We investigated the role of metabolic memory in a choice of strategies for adaptation to stress influences. We used a model of rat overeating in early ontogenesis from birth to 21 days of life and investigated the maintenance of formed metabolic pattern in later ontogenesis.The following characteristics were measured: somatometric indicators, resistance of animals to a temperature stress of 32ᵒC, thyroxin and triiodothyronine content in blood serum, NO-synthase activity, the content of lipid hydroperoxides and antioxidant enzymes in different organs in animals of 3, 20 and 31 months of age under standard conditions of maintenance in control animals and after overeating in the early ontogenesis.It is shown that the metabolic pattern formed on the background of overeating from birth to 21 days remains until the later stages of ontogeny. The forming metabolic pattern is characterized by elevated content of thyroxin, increase of NO-synthase activity in various tissues and particularly in the brain, a small increase of lipid hydroperoxides and reduced antioxidant activity of some enzymes. Animals that overeated in the early ontogenesis, are characterized by lower resistance to high temperatures and shorter life expectancy compared to the animals contained in the standard terms.

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Section: Introductionmentioning

confidence: 99%

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Ai¹,

Yu²

2016

J Gerontol Geriatr Res

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“…Earlier we assumed that conversion of animals to CRD induced the formation of specific epigenotypes providing extension of average and even maximal lifespan [18]. For epigenotypes providing potentially high life-span the cooperative changes in set of metabolic systems and first of all in prooxidant-antioxidant, hormonal and also nucleic-protein and lipid metabolism can be typical [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Caloric Restriction Diet Induces Specific Epigenotypes Associated with Life Span Extension

Bozhkov¹

2013

J. Nutr. Ther.

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The lifespan of Wistar rats on caloric restriction diet (CRD) is correlated with the changes in prooxidantantioxidant balance, in the contents of triiodothyronine, and thyroxin (epigenotype characteristics).It has been shown that in a month after the moment of one-month-old rats began to receive CRD the part (up to 15 %) of experimental animals died without any apparent cause, irrespective of the degree of calorie restriction (40 %, 57 % and 60 % weight-loss).The rest of animals with 40 %, 57 % and 60 % weight-loss had longer life span in comparison with control group.The CRD-induced life-span prolongation in animals was accompanied by the induction of specific epigenotypes featured by acceleration of the electron transfer rate in electron transport chain and subsequent reduced production of reactive oxygen species and increased antioxidant activity. The activity of glutathione reductase, glutathione transferase, NADHcytochrome C reductase, isocitrate dehydrogenase was elevated. The activity of Se-dependent glutathione peroxidase was higher more than 30 times as compared with control. Likewise, the epigenotypes of animals with 40 %, 57 % and 60 % weight-loss CR, were characterized by 37, 43 and 56 % decrease in triiodothyronine and 50, 25, 39 % decrease in tyrosine, respectively. The observed induction of specific epigenotypes is associated with higher life-span and is related to the multivariant metabolic strategies of adaptation to CRD.

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“…We have put forward a hypothesis that the selection of adaptation strategies is determined by the individual metabolic and epigenetic memory accumulated during the lifetime of the organism, in other words, its prehistory or genesis [11] [13] [14]. To put it in a simplified way, the more metabolic events that depend on the organism's prehistory are remembered, the narrower the range of potential metabolic "solutions" in response to changing environmental conditions is.…”

Section: Introductionmentioning

confidence: 99%

The Rate of Aging of the <i>Dunaliella viridis</i> Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect

Божков¹,

Kovaleva²,

Menzyanova³

et al. 2014

AAR

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Two sublines of microalgae Dunaliella viridis Teodor. were obtained: CuS-a subline sensitive to toxic concentration of copper ions and CuR-a subline resistant to toxic concentration of copper ions. The chronological aging of cultures was revealed in increase of DNA (polyploidization) and triacylglycerols (TAG) content in microalgae cells. The adaptation of D. viridis to toxic concentrations of copper ions resulted in formation of an adaptive epygenotype characterized by increased content of carbonylated proteins and decreased content of proline compared to the CuS-subline. The adaptation of D. viridis to toxic concentrations of copper ions resulted in the increase of the rate of chronological aging compared to the CuS-subline. Four subcultures with different rates of transplanting were obtained from each subline. The rate of replicative aging was shown to be dependent on the rate of chronological aging of subcultures (passage rate). The pre-adaptation of D. viridis to toxic concentrations of copper ions was accompanied by increase of accumulation rate of TAG and DNA in cells, which was interpreted as a sign of cellular aging during the progressive passages of the algae culture.

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Supposed role of “Metabolic memory” in formation of response reaction to stress factors in young and adult organisms

Cited by 7 publications

References 8 publications

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Caloric Restriction Diet Induces Specific Epigenotypes Associated with Life Span Extension

The Rate of Aging of the <i>Dunaliella viridis</i> Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect

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Supposed role of “Metabolic memory” in formation of response reaction to stress factors in young and adult organisms

Cited by 7 publications

References 8 publications

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Caloric Restriction Diet Induces Specific Epigenotypes Associated with Life Span Extension

The Rate of Aging of the &lt;i&gt;Dunaliella viridis&lt;/i&gt; Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect

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The Rate of Aging of the <i>Dunaliella viridis</i> Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect