Companies must respond to the growing expectations of their stakeholders, but also conduct their activities according to an ambitious responsible development approach, which means addressing the social and environmental practices associated with the development of its products. This commitment covers not only its own internal practices but also those of its suppliers. It involves identifying, managing, and optimizing sustainable practices in the supply network. Working towards this has become an extension of the responsibility and commitment, and is a key component of the overall business model and structure. However, supply chain management needs to deal with many difficulties to coordinate the actors of the supply chain. One of these difficulties is a wider range of risks. These include political, economic, social, environmental, legal, and technological risks. The objective of this chapter is to highlight, through the theoretical literature, some of the challenges and difficulties of supply chains and to constitute the strategies of resilience sustainable supply chain practices.