Supplementary Tables 6 through 14 from Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia

Abstract

<p>The following tables are supplied in the excel file due to their sizes: Table S6. Phosphosite Overlap. PhosphoScan mass-spectrometry in MOLM16 cells after 3 hour treatment with AZD1208 Table S7. Literature Entries. Full literature entries. Table S8. Model Target Functions. Target functions for AML general model and cell specific calibrated AML model. Table S9. AML genotype state. Nodes settings for model initialization for each cell-specific state. Table S10. Immediate downstream effect of modelled AML genotypes. Direct modelled effect of each genotype. Table S11. Cell-specific AML network model replicates response to treatments reported in external publications. Summary of experimental conclusions compared to model predictions. Table S12. Combination strategy. showing predicted activity for combinations of PI3K inhibitor, AKT inhibitor, MEK inhibitor, and AKT inhibitor with the PIM inhibitor AZD1208 across the 4 AML cell lines. Table S13. MOLM16_Res_DNAseq. Whole exome DNA-seq for PIM inhibition resistant populations of MOLM16 cell line. Table S14. BIOGRID Interactions. BIOGRID interactions between putative resistant deriving genes to the RAS/PI3K and/or the AKT/MTOR signaling pathways.</p>