Supplementary Figures S1-S5 from Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle

Abstract

<p>Supplementary Fig. S1. Representative in vivo and ex vivo images using a Maestro FLEX In Vivo Imaging System. Supplementary Fig. S2. Effect of the RF field on the temperature of brain tissues. Supplementary Fig. S3. Bright field microscopy and fluorescence was performed on an entire histological section of the brain stained with Hematoxylin-Eosin (green: CNS-1 glioma cells (GFP)). The same histological section shown in Fig. 4A was used (left panel). Higher magnification of the same section shows the H&E stain of an invasive site (right panel). Supplementary Fig. S4. Cytotoxicity of nanochain particles on CNS-1 cells. Supplementary Fig. S5. Weight progression of animals bearing orthotopic (A) CNS-1 or (B) 9L glioma tumors after DOX treatments.</p>